A Novel Missense WFS1 Variant: Expanding the Mutational Spectrum Associated with Nonsyndromic Low-Frequency Sensorineural Hearing Loss

Table 1

Summary of clinical data for members in the Chinese pedigree examined for genetic variants.

Subject	Gender	Age at test (years)	Age at onset (years)	Use of aminoglycoside	PTA (dB) right ear	PTA (dB) left ear	Tinnitus	Vertigo	Level of hearing impairment
II-7	F	70	30	No	68	66	No	No	Severe
III-6	F	55	21	No	60	60	No	No	Moderate
III-8	M	58	13	No	59	68	No	No	Severe
III-10	M	60	17	No	64	68	No	No	Severe
III-14	F	55	16	No	74	75	No	No	Severe
III-16	F	53	9	No	74	75	No	No	Severe
III-20	F	42	14	No	44	41	No	No	Moderate
III-22	M	44	14	No	46	53	No	No	Moderate
IV-2	F	30	11	No	36	41	No	No	Moderate
IV-8	M	30	—	No	13	13	No	No	Normal
IV-10	M	35	12	No	60	58	No	No	Moderate
IV-12	M	30	7	No	74	71	No	No	Severe
IV-14	F	26	—	No	11	14	No	No	Normal
IV-22	M	30	12	No	71	66	No	No	Severe
IV-29	M	16	8	No	38	38	No	No	Moderate
V-1	F	6	3	No	40	38	No	No	Moderate
V-3	M	13	1	No	85	85	No	No	Profound
V-8	M	10	—	No	20	20	No	No	Normal
V-9	M	4	—	No	14	14	No	No	Normal
V-15	M	5	5	No	29	29	No	No	Mild