Effects of CoQ10 Replacement Therapy on the Audiological Characteristics of Pediatric Patients with COQ6 Variants

Table 4

The audiological responses to oral CoQ10 administration according to the genotypes of COQ6 variants.

(a) c.189_191delGAA

	Regression gradient (dB/year)	value/methods
Subjects with c.189_191delGAA in one allele ( ears)		0.080
Subjects without c.189_191delGAA ( ears)		Clustered Wilcoxon rank sum test using the Datta-Satten method

(b) c.782C>T

	Regression gradient (dB/year)	value/methods
Subjects with c.782C>T in both alleles ( ears)		0.186
Subjects with c.782C>T in one allele ( ears)
Subjects without c.782C>T ( ears)		Clustered Wilcoxon rank sum test using the Datta-Satten method

(c) c.686A>C

	Regression gradient (dB/year)	value/methods
Subjects with c.686A>C in one allele ( ears)		0.026
Subjects without c.686A>C ( ears)		Clustered Wilcoxon rank sum test using the Datta-Satten method