Research Article
Effects of CoQ10 Replacement Therapy on the Audiological Characteristics of Pediatric Patients with COQ6 Variants
Table 4
The audiological responses to oral CoQ10 administration according to the genotypes of COQ6 variants.
(a) c.189_191delGAA |
| | Regression gradient (dB/year) | value/methods |
| Subjects with c.189_191delGAA in one allele ( ears) | | 0.080 | Subjects without c.189_191delGAA ( ears) | | Clustered Wilcoxon rank sum test using the Datta-Satten method |
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(b) c.782C>T |
| | Regression gradient (dB/year) | value/methods |
| Subjects with c.782C>T in both alleles ( ears) | | 0.186 | Subjects with c.782C>T in one allele ( ears) | | | Subjects without c.782C>T ( ears) | | Clustered Wilcoxon rank sum test using the Datta-Satten method |
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|
(c) c.686A>C |
| | Regression gradient (dB/year) | value/methods |
| Subjects with c.686A>C in one allele ( ears) | | 0.026 | Subjects without c.686A>C ( ears) | | Clustered Wilcoxon rank sum test using the Datta-Satten method |
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