Saikosaponin D Inducing Apoptosis and Autophagy through the Activation of Endoplasmic Reticulum Stress in Glioblastoma

Figure 1

SSD inhibited the proliferation of GBM cells and GBM cell morphology. Distinct cellular response of rat RG-2 GBM cell line, human GBM cell lines U87-MG, U251, and LN-428 were to 9 μM (S9), 12 μM (S12), 15 μM (S15), 18 μM (S18), and 21 μM (S21) SSD treatment for 24, 48, and 72 h. (a) Structure of Saikosaponin D. (b) CCK-8 cell proliferation assay. (c) The changes in cell morphology (40× magnification) observed by the inverted microscope. , , , and vs. CON group. The error bars, the deviation.

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