Research Article
Dexmedetomidine Alleviates Lung Oxidative Stress Injury Induced by Ischemia-Reperfusion in Diabetic Rats via the Nrf2-Sulfiredoxin1 Pathway
Figure 4
Pathological changes in lung tissue (original magnification, ×20). Paraformaldehyde-fixed sections of lung grafts were stained with hematoxylin and eosin. Diabetes mellitus induced lung injury and exacerbated lung ischemia-reperfusion injury. Dexmedetomidine could alleviate this lung injury. (a) CS group; (b) DS group; (c) CIR group; (d) DIR group; (e) DIRD group; (f) lung injury score (). CS: control+sham; DS: diabetes mellitus+sham; CIR: control+ischemia-reperfusion; DIR: diabetes mellitus+ischemia-reperfusion; DIRD: diabetes mellitus+ischemia-reperfusion+dexmedetomidine. In the DIRD group, the 3 μg/kg of DEX was used. vs. the CS group; # vs. the DS group; △ vs. the CIR group; § vs. the DIR group.
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