Comparative Analysis of the Metabolites and Biological Activity of Cultivated and Wild Lignosus rhinocerotis

Table 2

The metabolites of L. rhinocerotis were isolated and identified by UPLC-TOF-MS.

No.	Compounds	RT (min)	Ion mode	Molecular formula	ppm		Classification	LRR	LRS	LRW
1	Azlocillin	0.46	Pos	C20H23N5O6S	1.91	462.1450	Organonitrogen
2	3-(3-Hydroxyphenyl)-2-phenyl-4-[(E)-2-phenylethenyl]-2,3-dihydro-1-benzofuran-6-ol	0.88	Pos	C28H22O3	−2.68	424.1896	Other		—	—
3	Ergothioneine	0.91	Pos	C9H15N3O2S	0.32	230.0958	Organonitrogen
4	Cladrastin 7-O-glucoside	1.14	Neg	C24H26O11	−8.16	535.1417	Flavonoids		—	—
5	Lippioside II	1.15	Pos	C25H30O14	−4.05	537.1580	Terpenoids
6	Isoliquiritin	1.19	Pos	C21H22O9	−9.28	436.1563	Flavonoids		—
7	Anacardic acid	1.49	Pos	C22H30O3	8.65	381.1856	Phenolic acids		—	—
8	Angoluvarin	2.06	Pos	C30H28O6	4.98	502.2248	Flavonoids
9	5-((5Z,8Z,11Z,14Z)-Heptadeca-5,8,11,14-tetraen-1-yl)resorcinol	3.13	Pos	C23H32O2	8.66	379.2063	Other		—	—
10	Lupin isoflavone M	4.30	Pos	C25H28O8	−1.53	479.1669	Flavonoids		—	—
11	Cytochalasin B	5.21	Pos	C29H37NO5	8.84	502.2606	Alkaloids
12	Rubone	5.73	Pos	C20H22O7	−1.85	357.1325	Flavonoids
13	Valtrate	5.74	Pos	C10H12O5	0.87	195.0653	Terpenoids	—
14	Ginsenoside III	6.34	Pos	C48H80O19	1.00	978.5641	Terpenoids
15	Tephrone	6.40	Pos	C18H16O6	0.61	329.1021	Flavonoids
16	Cycloartomunin	6.44	Neg	C26H24O7	−0.06	493.1503	Flavonoids
17	5,2,4,5-Tetrahydroxy-3-(3-hydroxy-3-methylbutyl)-6,6-dimethylpyrano[2,3:7,8]flavone	6.48	Pos	C25H26O8	3.27	477.1534	Flavonoids
18	Artomunoxanthone	6.71	Neg	C26H24O7	−0.08	493.1503	Flavonoids
19	Brosimacutin G	6.92	Pos	C20H20O6	−1.46	357.1334	Flavonoids
20	5,7,3-Trihydroxy-4,5-dimethoxy-6,8-di-C-methylflavanone	7.20	Pos	C19H20O7	−0.76	343.1173	Flavonoids
21	Pibutidine	8.15	Neg	C19H24N4O3	−2.82	401.1820	Organonitrogen	—	—
22	3-Dehydroecdysone	9.08	Neg	C27H42O6	2.16	507.2973	Steroids	—	—
23	Cuscohygrine	9.14	Pos	C13H24N2O	2.03	225.1965	Alkaloids
24	(+)-Eudesmin	9.88	Pos	C22H26O6	−0.73	387.1799	Lignans
25	3,6-Hihydroxy-2-[3-methoxy-4-(sulfooxy)phenyl]-5-sulfino-3,4-dihydro-2H-1-benzopyran-7-olate	10.12	Neg	C16H16O11S2	−2.04	428.9946	Flavonoids
26	Armillaripin	10.22	Pos	C24H30O6	0.45	415.2117	Terpenoids
27	[5,6,7-Trihydroxy-4-oxo-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-3-yl]oxidanesulfonic acid	10.40	Neg	C15H12O12S	−3.96	414.9960	Flavonoids
28	4β-Hydroxywithanolide E	11.26	Pos	C28H38O8	−6.70	485.2500	Steroids		—
29	Phytuberin	11.40	Pos	C17H26O4	1.77	277.1803	Terpenoids
30	Phytol	11.64	Pos	C20H40O	−2.06	314.3411	Other		—	—
31	Dihydrodeoxy-8-epiaustdiol	11.68	Pos	C12H14O4	0.04	205.0859	Alkaloids
32	5-Dehydroepisterol	15.91	Pos	C28H44O	−2.18	379.3350	Steroids	—		—

RT: retention time; pos: positive ion mode; neg: negative ion mode; indicates detected; — indicates not detected.