Study the Mechanism of Gualou Niubang Decoction in Treating Plasma Cell Mastitis Based on Network Pharmacology and Molecular Docking

Table 4

Basic information of the top 15 pathways with the most target genes.

ID	Term	Count	value	Input
hsa05200	Pathways in cancer	22		BCL2L1/ERBB2/EGFR/HIF1A/RB1/MAPK1/MYC/IGF2/TCF7/CDKN2A/FOS/PPARG/VEGFA/CASP3/ESR1/CXCL8/CASP9/IL6/MMP9/MMP1/MMP2/BCL2
hsa05219	Bladder cancer	11		ERBB2/CDKN2A/CXCL8/EGFR/RB1/MAPK1/VEGFA/MMP9/MYC/MMP2/MMP1
hsa04933	AGE-RAGE signaling pathway in diabetic complications	12		NOS3/CASP3/CXCL8/IL6/MAPK1/VEGFA/VCAM1/ICAM1/SELE/COL3A1/MMP2/BCL2
hsa05161	Hepatitis B	12		PCNA/TLR2/CASP3/FOS/CXCL8/RB1/CASP9/IL6/MAPK1/MMP9/MYC/BCL2
hsa04151	PI3K-Akt signaling pathway	14		IGF2/BCL2L1/NOS3/ERBB2/EGFR/CASP9/IL6/INSR/MAPK1/VEGFA/MCL1/TLR2/MYC/BCL2
hsa05205	Proteoglycans in cancer	12		IGF2/ERBB2/CASP3/ESR1/EGFR/HIF1A/TLR2/MAPK1/VEGFA/MMP9/MYC/MMP2
hsa01522	Endocrine resistance	10		ERBB2/CDKN2A/ESR1/FOS/EGFR/RB1/MAPK1/MMP9/MMP2/BCL2
hsa04066	HIF-1 signaling pathway	10		ERBB2/NOS3/TIMP1/EGFR/HIF1A/IL6/INSR/MAPK1/VEGFA/BCL2
hsa04668	TNF signaling pathway	10		IRF1/CASP3/FOS/SELE/IL6/MAPK1/VCAM1/ICAM1/MMP9/MMP3
hsa05167	Kaposi sarcoma-associated herpesvirus infection	11		CASP3/FOS/CXCL8/HIF1A/CASP9/IL6/MAPK1/VEGFA/RB1/ICAM1/MYC
hsa04915	Estrogen signaling pathway	10		NOS3/FOS/EGFR/ESR1/CTSD/MAPK1/PGR/MMP9/MMP2/BCL2
hsa05206	MicroRNAs in cancer	12		ERBB2/TP63/CDKN2A/CASP3/CDC25C/EGFR/MAPK1/VEGFA/MCL1/MMP9/MYC/BCL2
hsa05215	Prostate cancer	9		ERBB2/TCF7/EGFR/RB1/CASP9/MAPK1/MMP9/MMP3/BCL2
hsa05212	Pancreatic cancer	8		BCL2L1/ERBB2/CDKN2A/EGFR/RB1/CASP9/MAPK1/VEGFA
hsa04926	Relaxin signaling pathway	9		NOS3/FOS/EGFR/MAPK1/VEGFA/MMP9/COL3A1/MMP2/MMP1