Research Article
A Systematic Review and Meta-analysis on the Occurrence of Biomarker Mutation in Colorectal Cancer among the Asian Population
Table 4
Subgroup analysis. Prevalence of BRAF gene mutation of patients with colorectal cancer stratified by study location.
| Subgroup | No. of Studies | Prevalence (%) | 95% CI | (%) | | Heterogeneity test | DF | |
| India | 4 | 11.7 | 0.062-0.210 | 73.69 | 11.401 | 3 | 0.010 | China | 7 | 4.0 | 0.025-0.063 | 93.42 | 91.205 | 6 | 0.001 | Iran | 3 | 4.7 | 0.004-0.403 | 96.16 | 52.129 | 2 | 0.001 | Taiwan | 1 | 1.1 | 0.003-0.043 | NA | NA | NA | NA | Japan | 5 | 6.9 | 0.044-0.107 | 55.86 | 9.062 | 4 | 0.060 | Thailand | 1 | 1.9 | 0.005-0.071 | NA | NA | NA | NA | South Korea | 1 | 3.3 | 0.011-0.096 | NA | NA | NA | NA | Singapore | 1 | 11.4 | 0.048-0.245 | NA | NA | NA | NA | Vietnam | 1 | 2.6 | 0.010-0.068 | NA | NA | NA | NA | Israel | 2 | 9.8 | 0.025-0.316 | 96.90 | 32.271 | 1 | 0.001 | Saudi Arabia | 1 | 2.2 | 0.014-0.035 | NA | NA | NA | NA | Indonesia | 1 | 14.0 | 0.064-0.278 | NA | NA | NA | NA | Malaysia | 1 | 2.3 | 0.003-0.144 | NA | NA | NA | NA | Overall | 29 | 5.6 | 0.039-0.080 | 94.00 | 466.942 | 28 | 0.001 | BRAF subgroup by period of study conduct | 2010 and below | 8 | 5.6 | 0.020-0.146 | 96.45 | 196.928 | 7 | 0.001 | After 2010 | 17 | 5.4 | 0.037-0.077 | 91.27 | 183.302 | 16 | 0.001 | BRAF subgroup by tumour stage | Early tumour stage1 | 10 | 40.1 | 0.293-0.518 | 62.297 | 62.297 | 9 | 0.005 | Late tumour stage2 | 10 | 59.9 | 0.482-0.707 | 95.59 | 62.297 | 9 | 0.005 | BRAF subgroup by tumour location | Colon | 10 | 67.9 | 0.577-0.766 | 54.421 | 19.746 | 9 | 0.020 | Rectum | 10 | 32.1 | 0.234-0.423 | 54.421 | 19.746 | 9 | 0.020 | BRAF subgroup by tumour grade | Poor | 11 | 30.4 | 0.189-0.450 | 88.066 | 83.794 | 10 | 0.001 | Moderate | 11 | 56.3 | 0.432-0.686 | 86.413 | 73.599 | 10 | 0.001 | Well | 11 | 10.2 | 0.056–0.179 | 69.996 | 33.329 | 10 | 0.001 |
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1Implies stages 1 and 2; 2implies stages 3 and 4.
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