Computational Clues of Immunogenic Hotspots in Plasmodium falciparum Erythrocytic Stage Vaccine Candidate Antigens: In Silico Approach

Table 2

Prediction of the posttranslational modification sites within 14 P. falciparum erythrocytic stage protein sequences.

PTM	AMA1	CyRPA	Eba175	MSP1	MSP3	MSP4	MSP6	Ralp1	RESA	Rh5	Ripr	Ron2	Sera5	Sera8
Phosphorylation
S	28	13	89	103	22	18	27	25	51	19	45	90	87	37
T	12	8	52	45	13	4	16	18	33	19	23	33	39	19
Y	25	10	28	39	9	3	3	14	22	15	38	33	17	25
Palmitoylation	2	1	2	3	—	1	—	2	2	1	4	—	3	5
Lysine acetylation	4	1	27	31	64	35	37	36	33	11	5	44	10	4
N-Glycosylation	4	3	15	11	4	2	2	4	4	2	11	13	2	2
O-Glycosylation	3	—	120	72	25	22	31	16	15	5	21	12	58	8

S: serine phosphorylation; T: tyrosine phosphorylation; Y: threonine phosphorylation.