Computational Clues of Immunogenic Hotspots in Plasmodium falciparum Erythrocytic Stage Vaccine Candidate Antigens: In Silico Approach
Table 7
Regional and global population coverage analysis of predicted HTL epitopes in 14 selected erythrocytic stage P. falciparum antigens.
Area
Class II MHC allele coverage
Coverage
Average hita
pc90b
Central Africa
99.21%
13.28
5.74
East Africa
99.17%
13.87
5.74
West Africa
99.43%
12.0
5.0
North Africa
72.9%
5.14
0.37
South Africa
7.65%
0.25
0.11
Central America
77.45%
4.23
0.44
North America
99.98%
17.77
11.7
South America
98.51%
13.54
5.51
West Indies
78.33%
5.49
0.46
Europe
99.83%
17.37
11.43
East Asia
76.66%
5.09
0.43
Northeast Asia
93.635
11.45
2.47
South Asia
98.92%
15.51
8.4
Southeast Asia
69.41%
3.08
0.33
Southwest Asia
70.01%
4.07
0.33
Oceania
93.69%
11.03
2.63
World
97.17%
14.21
4.57
Average
84.23
9.88
3.86
aAverage number of epitope hits/HLA combinations recognized by the population. bMinimum number of epitope hits/HLA combinations recognized by 90% of the population.
