Research Article

Clinical, Serological, and Genetic Characteristics of a Hungarian Myositis-Scleroderma Overlap Cohort

Table 1

Demographic, laboratory, and clinical results of SSc-myositis overlap vs. anti-Jo-1-positive patients.

SSc-myositis overlap patientsAnti-Jo-1-positive patients [22] value

Demographic data
Number of patients:3949
Male/female:9/307/42
Average age at disease (youngest-oldest): (13-76) (18-70)ns
Number/% of lcSSc22/56.41
Number/% of dcSSc17/43.59
Number/% of DM3/7.69
Number/% of PM36/92.31
Occurred simultaneously/initially diagnosed with myositis/scleroderma:23/4/12
Clinical results
ILD/alveolitis (no. of patients/%):24/71.7936/73.47ns
Arthritis/arthralgia (no. of patients/%):32/82.0543/87.76ns
Dysphagia (no. of patients/%):26/66.676/12.24<0.0001
Intestinal involvement except dysphagia (no of patients/%)11/28.215/10.20.03
Fever (no. of patients/%):7/17.9521/42.86ns
Raynaud’s phenomenon (no. of patients/%):38/97.4432/65.31<0.001
Renal involvement (no. of patients/%):5/12.82
Cardiac involvement (no. of patients/%):16/41.03
PAH (no. of patients/%):12/30.77
Mechanic’s hand (no. of patients/%)5/12.8216/32.65ns
Subcutaneous calcinosis (no. of patients/%)8/20.513/6.12ns
Livedo reticularis (no. of patients/%)2/5.1316/32.65<0.01
Laboratory results
ns
ns
SSA positivity (no. of patients/%)9/7.6917/34.69ns
<0.01

SD: standard deviation; CK: creatine kinase; LDH: lactate dehydrogenase; SSA: Sjögren’s-syndrome-related antigen A; ILD: interstitial lung disease; PAH: pulmonary arterial hypertension. Only age at diagnosis of myositis has Gaussian distribution in both groups; Welch’s -test was applied. Significance was calculated with independent samples -test or Mann–Whitney test, according to the distribution. Normality of the distributions was checked using Shapiro-Wilk test. Symptoms and laboratory parameters were compared between the two groups with Fisher’s exact test, applying Hochberg’s correction for multiple comparisons.