Anti-CD44 and EGFR Dual-Targeted Solid Lipid Nanoparticles for Delivery of Doxorubicin to Triple-Negative Breast Cancer Cell Line: Preparation, Statistical Optimization, and In Vitro Characterization

Figure 5

Response 3D plots for alteration in the EE% values. In the lowest concentration of Tween 80 (i.e., 1%), the values for EE% fell dramatically by increasing the concentration ratio of GMS/lecithin from 0.5 to 1.25%. Further increase in the concentration ratio up to 2.0 resulted in a slight and nonsignificant reduction in the EE%. On the other hand, in the highest concentration of Tween 80 (i.e., 4.0), the values for EE% of the nanoparticles were increased by increasing the concentration ratio.