Anti-CD44 and EGFR Dual-Targeted Solid Lipid Nanoparticles for Delivery of Doxorubicin to Triple-Negative Breast Cancer Cell Line: Preparation, Statistical Optimization, and In Vitro Characterization

Table 1

Ranges and constrains.

Independent variables (factors)	Levels
	-1	+1
Concentration ratio GMS/lecithin (A)	0.5	2.0
Amount of Tween 80 (B) (mg)	1.0	4.0
Dependent variables (responses)	Constrains
Size (nm) ()	Minimized
PDI ()	Minimized
EE% ()	Maximized