Remimazolam Requires Less Vasopressor Support during Induction and Maintenance of General Anesthesia in Patients with Severe Aortic Stenosis Undergoing Transcatheter Aortic Valve Replacement: A Retrospective Analysis from a Single Center

Table 1

Patients’ background data. There was no difference between the three groups in terms of patient background factors. There were no differences noted regarding the severity of AS which was determined by mean and max pressure gradients and peak velocity over the valve. Values are shown as median (interquartile range) or number (%). A was considered to indicate statistical significance. BMI: body mass index; STS: Society of Thoracic Surgeons; TAVI: transcatheter aortic valve implantation; PG: pressure gradient; LVEF: left ventricular ejection fraction.

	Group R/R	Group P/S	Group M/P	value
	Age (years)	83 [80.5-85.5]	84 [82-86]		82 [80-83]	0.63
Sex male/female ()	3/12	4/9	4/10	0.78
Height (cm)	150 [145-150.5]	149 [144-156]	150 [148-162]	0.56
Weight (kg)	52.8 [44.5-60]	51.7 [44-57]	51.7 [43-64.5]	0.92
BMI (kg/m^2)	22.0 [21.2-27.2]	22.0 [20.2-25.8]	22.6 [20.0-26.9]	0.59
Logistic EuroScore (%)	11.0 [8.7-14.4]	10.0 [7.6-14.8]	10.7 [9.9-13.2]	0.62
STS score (%)	5.0 [3.7-5.4]	5.0 [3.7-6.8]	5.0 [4.0-7.8]	0.31
Clinical Frailty Scale	4 [4-4.5]	4 [3-4]	4 [3.8-4]	0.70
Indwelling TAVI valve type (SAPIEN3/Evolut-R)	12/3	10/3	12/2
Aortic valve area (cm^2)	0.76 [0.50-0.81]	0.70 [0.60-0.80]	0.65 [0.59-0.83]	0.33
Mean PG (mg/dL)	54.8 [41.6-71.0]	50.1 [40.0-69.0]	55.9 [46.0-60.5]	0.85
Max PG (mg/dL)	74.9 [60.5-94.4]	81.4 [70.0-115.0]	82.5 [59.5-89.3]	0.74
Peak velocity (m/s)	4.5 [4.2-4.9]	4.5 [4.2-5.4]	4.6 [4.1-4.9]	0.73
LVEF (%)	65 [61-68]	62 [59-66]	62 [59-64]	0.21
Aortic regurgitation graded more than mild (%)	7 (47)	7 (54)	9 (64)	0.63
Hypertension n (%)	11 (73)	12 (92)	10 (71)	0.34
Diabetes mellitus (%)	3 (20)	4 (31)	3 (21)	0.77
Hyperlipidemia (%)	7 (47)	7 (54)	5 (35)	0.63
Pacemaker implanted (%)	0 (0)	1 (8)	3 (21)	0.13