Remimazolam Requires Less Vasopressor Support during Induction and Maintenance of General Anesthesia in Patients with Severe Aortic Stenosis Undergoing Transcatheter Aortic Valve Replacement: A Retrospective Analysis from a Single Center

Table 2

Anesthetics, vasopressor agents, and vasodilators are used for anesthesia induction and maintenance. Values are shown as median (interquartile range) or number (%). A was considered to indicate statistical significance. compared to Group R/R; compared to Group R/R.

	Group R/R	Group P/S	Group M/P	value
	Induction of anesthesia
Fentanyl (μg/kg)	1.7 [0-1.8]	1.5 [0-1.8]	1.5 [0-2.1]	0.87
Remifentanil (μg/kg/min)	0.24 [0.20-0.26]	0.30 [0.24-0.36]	0.33 [0.29-0.36]	0.12
Remimazolam (mg/kg)	0.18 [0.16-0.22]	—	—	—
Propofol (mg/kg)	—	1.06 [0.99-1.14]	—	—
Midazolam (mg/kg)	—	—	0.05 [0.04-0.06]	—
Use of vasopressor (with/without use)	9/6	13/0	12/2	0.02
Ephedrine (mg)	2 [0-4]	8 [8-12]	5 [0-15]	<0.001
Phenylephrine (mg)	0 [0-0.08]	0.15 [0.10-0.20]	0.21 [0.04-0.40]	0.005
Maintenance of anesthesia
Remifentanil (μg/kg/min)	0.22 [0.19-0.32]	0.15 [0.14-0.19]	0.20 [0.19-0.23]	0.06
Remimazolam (mg/kg/hr)	0.48 [0.30-0.55]	—	—	—
Sevoflurane (%)	—	1.0 [1.0-1.5]	—	—
Propofol (TCI, μg/mL)	—	—	1.0 [1.0-1.12]	—
Noradrenaline (μg/kg/min)	0.019 [0.015-0.039]	0.042 [0.035-0.045]	0.048 [0.040-0.059]	0.002
Carperitide (with/without use)	3/12	4/9	7/7	0.22
Carperitide (μg/kg/h)	1.04 [0.56-1.37]	0.90 [0.75-1.04]	0.94 [0.84-1.04]	0.96
Awakening from anesthesia
Flumazenil (with/without use)	9/6	—	—
Flumazenil (mg)	0.5 [0.2-0.5]	—	—