Use of Autologous Serum Eye Drops with Contact Lenses in the Treatment of Chemical Burn-Induced Bilateral Corneal Persistent Epithelial Defects

Table 2

Studies on the combination of bandage contact lenses and autologous serum eye drops for corneal PED treatment.

	This study	Schrader et al. [6]	Choi and Chung [7]	Lee et al. [8]	Wang et al. [9]
Study design	Retrospective study	Retrospective study	Prospective study	Prospective study	Retrospective study
Patient number	8	5	8	21	12
Lesion eye	Bilateral	Four unilateral; One patient treated two times in 2 years	Unilateral	Unilateral	Unilateral
Pathogenesis of PED	Chemical burn	Rheumatoid sterile corneal ulcer, neurotrophic keratopathy, and partial limbal stem cell deficiency	Sjögren-type dry eye syndrome, graft-versus-host disease, toxic keratitis, limbal cell deficiency, superior limbic keratoconjunctivitis, and neurotrophic keratitis	Chemical burn with partial limbal stem cell deficiency, corneal epithelial debridement caused by mechanical debridement during pars plana vitrectomy, postinfectious, and neurotrophic keratopathy	Postinfectious
Type of contact lens	Silicone–hydrogel CLs	FDA group IV hydrogel lenses	Silicone–hydrogel CLs	Silicone–hydrogel CLs	Silicone–hydrogel CLs
Autologous serum concentration	20% (v/v)	20% (v/v)	50% (v/v)	20% (v/v)	20% (v/v)
Frequency of autologous serum eye drop application	Every 2 hours	8 times a day	Every 2 hours	Every 2 hours	Every 2 hours
Treatment response	All healed in 2 weeks	All healed in  days	All healed in days	All healed in 3 weeks	All healed in 2 weeks

Abbreviations: PED: persistent epithelial defect; CLs: contact lenses; FDA: US Food and Drug Administration; v/v: volume/volume percent.