[Retracted] Toxicological and Teratogenic Effect of Various Food Additives: An Updated Review

Table 1

Safety evaluation of certain food additives with examples and INS number.

S. no.	Functional class	Description	Example of food additive	INS no.	Acceptable daily intake (ADI)	Median lethal dose (LD50)
1.	Preservative	Prolong the shelf life of foods by protecting them against deterioration caused by microorganisms.	(a) Sodium benzoate; (b) Potassium benzoate	211; 212	0-5 mg/kg bw; 0-5 mg/kg bw	Oral rat >4070 mg/kg [92]; Rat >10,000 mg/kg [93]
2.	Sweeteners	Impart a sweet taste to foods or in tabletop sweeteners.	Aspartame	951	40 mg/kg bw	Oral rat >10,000 mg/kg [94]
3.	Stabilizers	Maintain the physicochemical state of a food stuff.	Carrageenan	407	75 mg/kg bw	Oral rat >5,000 mg/kg [95]
4.	Colouring agents	Add or restore colour in a food and include natural constituents of foods and natural sources.	Tartrazine	102	0-10 mg/kg bw	Mouse >6250 mg/kg [96]