Mechanical Stretch Promotes Macrophage Polarization and Inflammation via the RhoA-ROCK/NF-κB Pathway

Figure 2

Mechanical stretch promoted the expression of M1-related mRNA and cytokine secretion of RAW264.7 macrophages. (a) IL-1β, IL-6, TNF-α, and iNOS concentration in the cellular supernatant after 5%, 10%, and 15% Elong mechanical stretch for 8 h. Control indicates cells were cultured at static condition. (b) IL-1β, IL-6, TNF-α, and iNOS mRNA expression levels after 5%, 10%, and 15% elongation mechanical stretch for 8 h. Control indicates cells were cultured at static condition. The results are expressed as the (). Compare to control, and .

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