Vitamin D Receptor Gene Polymorphisms and the Risk of CIN2+ in Shanxi Population
Table 2
Distribution of VDR SNP genotypes versus alleles in the case and control groups.
Genotype/allele
Case (%)
Control (%)
Crude OR (95% CI)
value
Adjusted (95% CI)
value
FOKIa
FF
28 (14.89)
42 (22.34)
—
—
—
—
Ff
77 (41.96)
84 (44.68)
1.38 (0.78-2.43)
0.273
1.47 (0.81-2.67)
0.205
ff
83 (44.15)
62 (32.98)
2.01 (1.12-3.59)
0.019
2.18 (1.19-3.99)
0.012
Ff+ff
160 (85.11)
146 (77.66)
1.64 (0.97-2.79)
0.065
1.77 (1.02-3.08)
0.041
F
133 (35.37)
168 (44.68)
—
—
—
—
f
243 (64.63)
208 (55.32)
1.48 (1.10-1.98)
0.009
—
—
BsmIa
BB
15 (7.98)
18 (9.57)
—
—
—
—
Bb
61 (32.45)
69 (36.70)
1.06 (0.49-2.28)
0.880
0.92 (0.41-2.08)
0.845
bb
112 (59.57)
101 (53.73)
1.33 (0.64-2.78)
0.447
1.25 (0.58-2.71)
0.571
Bb+bb
173 (92.02)
170 (90.43)
1.22 (0.60-2.50)
0.585
1.12 (0.53-2.39)
0.762
B
91 (24.20)
105 (27.93)
—
—
—
—
b
285 (75.80)
271 (72.07)
1.21 (0.88-1.68)
0.245
—
—
ApaIa
AA
22 (11.70)
31 (16.49)
—
—
—
—
Aa
92 (48.94)
85 (45.21)
1.53 (0.82-2.84)
0.183
1.38 (0.72-2.66)
0.227
aa
74 (39.36)
72 (38.30)
1.45 (0.77-2.74)
0.253
1.34 (0.68-2.63)
0.394
Aa+aa
166 (88.30)
157 (83.51)
1.49 (0.83-2.68)
0.184
1.36 (0.73-2.54)
0.332
A
136 (36.17)
148 (39.36)
—
—
—
—
a
240 (63.83)
228 (60.64)
1.15 (0.85-1.54)
0.367
—
—
TaqIa
TT
29 (15.43)
51 (27.13)
—
—
—
—
Tt
121 (64.36)
105 (55.85)
2.03 (1.20-3.43)
0.008
1.94 (1.12-3.35)
0.018
tt
38 (20.21)
32 (17.02)
2.09 (1.09-4.02)
0.028
2.14 (1.07-4.28)
0.031
Tt+tt
159 (84.57)
137 (72.87)
2.04 (1.23-3.40)
0.006
1.98 (1.17-3.37)
0.012
T
179 (47.61)
207 (55.05)
—
—
—
—
t
197 (52.39)
169 (44.95)
1.35 (1.01-1.80)
0.041
—
—
a All genotypes in the control group followed the Hardy-Weinberg equilibrium law. b Multivariate logistic regression adjusting for age, smoking, menopause, and age at first sex).