Vitamin D Receptor Gene Polymorphisms and the Risk of CIN2+ in Shanxi Population

Table 2

Distribution of VDR SNP genotypes versus alleles in the case and control groups.

Genotype/allele	Case (%)	Control (%)	Crude OR (95% CI)	value	Adjusted (95% CI)	value
FOKI^a
FF	28 (14.89)	42 (22.34)	—	—	—	—
Ff	77 (41.96)	84 (44.68)	1.38 (0.78-2.43)	0.273	1.47 (0.81-2.67)	0.205
ff	83 (44.15)	62 (32.98)	2.01 (1.12-3.59)	0.019	2.18 (1.19-3.99)	0.012
Ff+ff	160 (85.11)	146 (77.66)	1.64 (0.97-2.79)	0.065	1.77 (1.02-3.08)	0.041
F	133 (35.37)	168 (44.68)	—	—	—	—
f	243 (64.63)	208 (55.32)	1.48 (1.10-1.98)	0.009	—	—
BsmI^a
BB	15 (7.98)	18 (9.57)	—	—	—	—
Bb	61 (32.45)	69 (36.70)	1.06 (0.49-2.28)	0.880	0.92 (0.41-2.08)	0.845
bb	112 (59.57)	101 (53.73)	1.33 (0.64-2.78)	0.447	1.25 (0.58-2.71)	0.571
Bb+bb	173 (92.02)	170 (90.43)	1.22 (0.60-2.50)	0.585	1.12 (0.53-2.39)	0.762
B	91 (24.20)	105 (27.93)	—	—	—	—
b	285 (75.80)	271 (72.07)	1.21 (0.88-1.68)	0.245	—	—
ApaI^a
AA	22 (11.70)	31 (16.49)	—	—	—	—
Aa	92 (48.94)	85 (45.21)	1.53 (0.82-2.84)	0.183	1.38 (0.72-2.66)	0.227
aa	74 (39.36)	72 (38.30)	1.45 (0.77-2.74)	0.253	1.34 (0.68-2.63)	0.394
Aa+aa	166 (88.30)	157 (83.51)	1.49 (0.83-2.68)	0.184	1.36 (0.73-2.54)	0.332
A	136 (36.17)	148 (39.36)	—	—	—	—
a	240 (63.83)	228 (60.64)	1.15 (0.85-1.54)	0.367	—	—
TaqI^a
TT	29 (15.43)	51 (27.13)	—	—	—	—
Tt	121 (64.36)	105 (55.85)	2.03 (1.20-3.43)	0.008	1.94 (1.12-3.35)	0.018
tt	38 (20.21)	32 (17.02)	2.09 (1.09-4.02)	0.028	2.14 (1.07-4.28)	0.031
Tt+tt	159 (84.57)	137 (72.87)	2.04 (1.23-3.40)	0.006	1.98 (1.17-3.37)	0.012
T	179 (47.61)	207 (55.05)	—	—	—	—
t	197 (52.39)	169 (44.95)	1.35 (1.01-1.80)	0.041	—	—

^a All genotypes in the control group followed the Hardy-Weinberg equilibrium law. ^b Multivariate logistic regression adjusting for age, smoking, menopause, and age at first sex).