Key Genes Are Associated with the Prognosis of Glioma, and Melittin Can Regulate the Expression of These Genes in Glioma U87 Cells

Figure 4

MT-induced differentially expressed genes. (a) Number of up- and downregulated genes. (b) Groups of the differentially expressed mRNAs: CON-1, CON-2, and CON-3 (0 nM MT); MT-1, MT-2, and MT-3 (150 nM). (c) Presentation of the volcano plot of DEGs identified from the RNA-seq. Red plots stand for upregulated genes, and blue plots indicate downregulated genes with the following criteria: and . Grey plots indicate nonsignificantly expressed genes. The ordinate shows the -log10 of the adjusted value for each gene, symbolizing the strength of the association. (d) GO analysis of the differentially expressed genes in cellular component, biological process and molecular function. (e) KEGG pathway analyzes the pathways involved in MT regulation.

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