Rhein Inhibits the Progression of Chemoresistant Lung Cancer Cell Lines via the Stat3/Snail/MMP2/MMP9 Pathway

<div>Rhein suppresses cell proliferation in chemosensitive and chemoresistant lung cancer cells. (a) Inhibition of A549 and A549/Taxol cell survival treated with Taxol (0, 15, 30, 60, and 120 <i>μ</i>M). (b) Inhibition of PC9 and PC9/GD cell survival treated with gefitinib (0, 0.5, 1, 2, and 4 <i>μ</i>M). (c) Inhibition of A549, A549/Taxol, PC9, and PC9/GD cell survival treated with rhein (0, 5, 25, 50, and 100 <i>μ</i>M) for 24 h. The inhibition rate was calculated in comparison to control cells. The number of cells in the control group was taken as 100%. Data are from three independent experiments. 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BioMed Research International

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Figure 1

Figure 1: Rhein Inhibits the Progression of Chemoresistant Lung Cancer Cell Lines via the Stat3/Snail/MMP2/MMP9 Pathway 