Paxlovid: Mechanism of Action, Synthesis, and In Silico Study

Table 1

The influence of various reaction parameters on the selectivity and efficiency of synthetic compounds.

Compounds	Temperature	Time	Solvent	pH	Yield	Ref.
	4°C	18 h	(100% DMSO) for a molar ratio of approximately 1 : 7	6.00	18.4 mg, 30.7 μmol, 32%	[14]
	4°C	18 h	(100% DMSO) for a molar ratio of approximately 1 : 5	7.00	18 mg, 30 μmol, 21%	[14]
	4°C	24 h	—	6.00	160.93 g, 322 mmol, 97%	[14]