Performance of HCV Antigen Testing for the Diagnosis and Monitoring of Antiviral Treatment: A Systematic Review and Meta-Analysis

Table 3

Sensitivity (SE), specificity (SP), positive predictive value (PPV), negative predictive value (NPV), correct classification (accuracy), and Kappa for studies.

Article	SE	SP	PPV	NPV	Accuracy	Kappa
Lamoury, 2018 [28]	97.7	100.0	100.0	94.1	98.3	97.1
Lamoury, 2018 [28]	88.6	96.9	98.7	75.6	90.8	89.7
Adland, 2018 [45]	94.5	100.0	100.0	90.5	96.4	95.3
Nguyen, 2018 [24]	87.2	100.0	100.0	57.7	89.1	87.8
Wasitthankasem, 2017 [29]	100	97.1	99.1	100.0	99.3	98.0
Alonso, 2017 [50]	96.4	100.0	100.0	96.6	98.2	97.2
Mohamed, 2017 [27]	99.1	94.4	98.3	97.1	98.0	96.7
Mohamed, 2017 [27]	76.7	97.3	98.9	57.1	81.7	80.6
Talal, 2017 [47]	97.9	100.0	100.0	98.4	99.1	98.1
Rockstroh, 2017 [15]	99.5	100.0	100.0	99.4	99.7	98.7
Chevaliez, 2014 [14]	100.0	100.0	100.0	100.0	100.0	98.9
Garbuglia, 2014 [56]	91.4	-	100.0	-	91.4	89.6
Heidrich, 2014 [57]	92.6	98.9	99.6	83.9	94.4	93.2
Mederacke, 2012 [25]	95.7	100.0	100.0	25.0	95.8	93.9
Mederacke, 2012 [25]	100.0	90.9	94.6	100.0	96.5	95.4
Mederacke, 2012 [25]	100.0	100.0	100.0	100.0	100.0	98.9
Yuksel, 2011 [69]	94.3	97.9	99.1	87.0	95.3	94.2
Kesli, 2011 [60]	96.3	100.0	100.0	89.7	97.2	95.9
Moscato, 2011 [30]	100.0	-	97.1	-	97.1	95.2
Moscato, 2011 [30]	100.0	100.0	100.0	100.0	100.0	98.4
Miedouge, 2010 [61]	98.9	100.0	100.0	88.9	99.0	97.3
Ross, 2010 [62]	100.0	100.0	100.0	100.0	100.0	98.8
Medhi, 2008 [63]	96.4	100.0	100.0	86.7	97.1	95.7
Reddy, 2006 [34]	14.3	97.8	60.0	83.0	82.0	80.4
Bouzgarrou, 2005 [64]	83.6	88.9	99.0	29.6	84.0	82.5
Gonzalez, 2005 [21]	68.9	100.0	100.0	74.7	83.8	82.8
Massaguer, 2005 [65]	92.1	100.0	100.0	65.5	93.1	91.7
Fabrizi, 2005 [66]	92.7	97.4	94.7	96.5	95.9	94.8
Lorenzo, 2004 [67]	87.7	40.0	95.9	16.7	84.9	83.2
Schuttler, 2004 [20]	98.0	96.2	99.0	92.7	97.6	96.3
Tanaka, 2000 [68]	97.3	100.0	100.0	98.5	99.0	98.0
Lucejko, 2000 [40]	97.1	99.6	99.6	96.7	98.2	97.2
Catlett, 2019 [41]	100.0	99.2	98.1	100.0	99.5	98.3
Catlett, 2019 [41]	100.0	96.4	90.7	100.0	97.3	96.1
Garcia, 2019 [42]	97.7	97.7	96.9	98.3	97.7	96.7
Mederacke, 2012 [25]	98.3	96.6	98.9	95.0	97.9	96.6
Feng, 2020 [39]	97.0	97.6	92.4	99.1	97.5	96.2
Lin, 2020 [18]	97.3	98.1	99.1	94.5	97.5	96.4
Mean value	95.3			94.0