Cloning and Characterization of the Gene Encoding HMGS Synthase in Polygonatum sibiricum

Figure 1

Synthetic pathway of plant terpenes. AACT: acetoacetyl-CoA acyltransferase; HMGS: 3-hydroxy-3-methylglutaryl-CoA synthase; HMGR: 3-hydroxy-3-methylglutaryl-CoA reductase; MK: mevalonic acid kinase; PMK: phosphomevalonate kinase; MDC: mevalonate-5-pyrophosphate decarboxylase; DXPS: 1-deoxy-D-xylulose-5-phosphate synthase; DXR: 1-deoxy-D-xylulose-5-phosphate reductoisomerase; MCT: 2-C-methyl-d-erythritol 4-phosphate cytidylyltransferase; CMK: 4-(cytidine 5-diphospho)-2-C-methyl-D-erythritol kinase; MDS: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; HDS: 4-hydroxy-3-methylbut-2-enyldiphosphate synthase; IPPI: IPP isomerase; GPPS: geranyl pyrophosphate synthase; FPPS: farnesyl pyrophosphate synthase; GGPPS: geranylgeranyl diphosphate synthase; SS: squalene synthase; SE: squalene epoxidase; DS: dammarenediol-II synthase; HDR: 4-hydroxy-3-methylbut-2-enyldiphosphate reductase; GAS: germacrene A synthase; GDS: germacrene D synthase; QHS1: beta-caryophyllene synthase.