Metabolomics of Esophageal Squamous Cell Carcinoma Tissues: Potential Biomarkers for Diagnosis and Promising Targets for Therapy

Figure 3

Multivariate analysis and identification by PCA, PLS-DA, and OPLS-DA. (a, b) Scatter plots analyzed by PCA; (c, e, g, i) PLS-DA (c, e) and OPLS-DA (g, i) showed that the metabolism of cancer tissues was different from that of adjacent tissues; (d, f, h, j) permutation test to test the reliability of the model. Note: CA: esophageal squamous cell carcinoma tissue; NO: control group (adjacent noncancerous tissue); QC: quality control sample.

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