Research Article
Molecular Hydrogen Inhibits Colorectal Cancer Growth via the AKT/SCD1 Signaling Pathway
Table 1
SCD1 status and its association with clinicopathological characteristics in CRC patients.
| SCD1 expression | Characteristics | Number | High | (%) | Low | (%) | |
| Gender | | | | | | | Male | 299 | 203 | 67.90% | 96 | 32.10% | 0.15 | Female | 192 | 142 | 73.90% | 50 | 26.10% | | Age (years) | | | | | | | ≤50 | 64 | 41 | 64.10% | 23 | 35.90% | 0.24 | >50 | 427 | 304 | 71.20% | 123 | 28.80% | | Location | | | | | | | Right side colon | 112 | 76 | 67.80% | 36 | 32.10% | 0.53 | Left side colon | 93 | 58 | 62.40% | 35 | 37.60% | | Rectum | 286 | 211 | 73.80% | 75 | 26.20% | | Mucin production | | | | | | | With | 46 | 40 | 86.90% | 6 | 13.10% | 0.07 | Without | 425 | 305 | 71.76% | 120 | 28.20% | | Tumor differentiation | | | | | | | Poor | 106 | 68 | 64.20% | 38 | 35.80% | 0.12 | Moderate/well | 385 | 277 | 71.90% | 108 | 28.10% | | Tumor diameter | | | | | | | ≤ 5 cm | 269 | 190 | 70.60% | 79 | 29.40% | 0.85 | >5 cm | 222 | 155 | 69.80% | 67 | 30.20% | | Tumor stage | | | | | | | | 288 | 191 | 66.30% | 97 | 33.70% | 0.02 | III | 203 | 154 | 75.90% | 49 | 24.10% | | Bowel wall invasion (T) | | | | | | | | 91 | 62 | 68.10% | 29 | 31.90% | 0.62 | | 400 | 283 | 70.80% | 117 | 29.20% | | Lymph node metastasis () | | | | | | | Without | 288 | 191 | 66.30% | 97 | 33.70% | 0.02 | With | 203 | 154 | 75.90% | 49 | 24.10% | | Lymphovascular invasion | | | | | | | No | 335 | 244 | 72.80% | 91 | 27.20% | 0.07 | Yes | 156 | 101 | 64.70% | 55 | 35.30% | | Alcohol intake | | | | | | | Never | 387 | 275 | 71.10% | 112 | 28.90% | 0.46 | Ever | 104 | 70 | 67.30% | 34 | 32.70% | | Smoking | | | | | | | Ever | 137 | 87 | 63.50% | 50 | 36.50% | 0.043 | Never | 354 | 258 | 72.90% | 96 | 27.10% | | Cancer family history | | | | | | | Yes | 93 | 68 | 73.10% | 25 | 26.90% | 0.25 | No | 119 | 95 | 79.80% | 24 | 20.20% | | Unknown | 279 | | | | | | Colorectal family history | | | | | | | Yes | 29 | 18 | 62.10% | 11 | 37.90% | 0.047 | No | 183 | 144 | 78.70% | 39 | 21.30% | | Unknown | 279 | | | | | | MSI status | | | | | | | MSI | 68 | 46 | 67.60% | 22 | 32.40% | 0.61 | MSS | 423 | 299 | 70.70% | 124 | 29.30% | | KRAS status | | | | | | | Mutation | 212 | 147 | 69.30% | 65 | 30.70% | 0.7 | Wild type | 279 | 198 | 70.90% | 81 | 29.10% | |
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