Gut Microbiome Characteristics in Mothers and Infants According to the Presence of Atopic Dermatitis
Table 2
Differential microbial taxa in group comparisons determined using DESeq2.
Compared groups
BaseMean
log2FoldChange
value
Phylum
Species
IAD over IHC
29.46
-8.33
0.0024
Actinobacteria
Bifidobacterium
34.72
-22.91
<0.001
Actinobacteria
Bifidobacterium
861.94
-4.03
0.0021
Actinobacteria
Bifidobacterium breve
14.16
23.05
<0.001
Bacteroidetes
Bacteroides
5.79
6.12
0.0432
Bacteroidetes
Bacteroides
5.98
-6.03
0.0430
Firmicutes
Clostridium paraputrificum
11.37
22.76
<0.001
Firmicutes
Dorea longicatena
6.20
6.22
0.0399
Firmicutes
Faecalibacterium
7.95
6.58
0.0297
Firmicutes
Ruminococcus lactaris
21.00
-22.21
<0.001
Firmicutes
unknown_Clostridiales
8.72
-6.57
0.0319
Firmicutes
unknown_Lachnospiraceae
29.54
-22.68
<0.001
Verrucomicrobia
Akkermansia muciniphila
MAD over MHC
19.65
5.38
0.0417
Bacteroidetes
Prevotella
10.11
-6.57
0.0320
Firmicutes
Coprococcus eutactus
22.50
-22.00
<0.001
Firmicutes
Ruminococcus lactaris
21.23
-7.64
0.0032
Firmicutes
unknown_Clostridiales
24.46
-7.84
0.0007
Firmicutes
unknown_Clostridiales
7.01
-6.04
0.0488
Verrucomicrobia
Akkermansia muciniphila
AD, atopic dermatitis, IAD, infant AD; IHC, infant healthy controls; MAD, mother AD; MHC, mother healthy controls. Criteria for inclusion: mean of normalized counts for all samples (BaseMean) >1 and value <0.05.
