Studies on Virulence and Extended-Spectrum β-Lactamase-Producing Uropathogenic Escherichia coli Isolates and Therapeutic Effect of Fosfomycin in Acute Pyelonephritis Mice

Figure 2

Effect of fosfomycin treatment on the UPEC-induced acute pyelonephritis model. Bacterial load (in log CFUs) in the urine (a), bladder (b), and kidney (c) of control and infected mice treated with fosfomycin. (d) Histopathological examination of bladder (A–C) and kidney (D‑F) sections. (A) Bladder, healthy control group; (B) bladder, APN group; (C) bladder, 800 mg/kg fosfomycin group; (D) kidney, healthy control group; (E) kidney, vehicle APN group; (F) kidney, 800 mg/kg fosfomycin group. Arrow in (A–C): bladder mucosa; arrow in (C–E): glomerular endothelial cells.

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