Research Article

A Network Pharmacology-Based Study on Vital Pharmacological Pathways and Targets of Eucommiae Cortex Acting on Osteoporosis

Table 3

Eucommiae Cortex bioactive compound-related osteoporosis targets.

GENE NAMEProtein nameENTRY

AHRAryl hydrocarbon receptorP35869
AKT1RAC-alpha serine/threonine-protein kinaseP31749
ALBSerum albuminP02768
ALOX5Arachidonate 5-lipoxygenaseP09917
ARAndrogen receptorP10275
BAXApoptosis regulator BAXQ07812
BCL2Apoptosis regulator Bcl-2P10415
BCL2L1Bcl-2-like protein 1Q07817
BIRC5Baculoviral IAP repeat-containing protein 5O15392
CASP3Caspase-3P42574
CASP8Caspase-8Q14790
CASP9Caspase-9P55211
CAV1Caveolin-1Q03135
CCL2C-C motif chemokine 2P13500
CCNB1G2/mitotic-specific cyclin-B1P14635
CCND1G1/S-specific cyclin-D1P24385
CD40LGCD40 ligandP29965
CDKN1ACyclin-dependent kinase inhibitor 1P38936
CHRM3Muscarinic acetylcholine receptor M3P20309
IKKAInhibitor of nuclear factor kappa-B kinase subunit alphaO15111
CLDN4Claudin-4O14493
CRPC-reactive proteinP02741
CTNNB1Catenin beta-1P35222
CXCL2C-X-C motif chemokine 2P19875
CXCL8Interleukin-8P10145
CYP1A1Cytochrome P450 1A1P04798
CYP1A2Cytochrome P450 1A2P05177
CYP3A4Cytochrome P450 3A4P08684
DUOX2Dual oxidase 2Q9NRD8
EGFPro-epidermal growth factorP01133
EGFREpidermal growth factor receptorP00533
ERBB2Receptor tyrosine-protein kinase erbB-2P04626
ERBB3Receptor tyrosine-protein kinase erbB-3P21860
F3Tissue factorP13726
FOSProto-oncogene c-FosP01100
GJA1Gap junction alpha-1 proteinP17302
GSK3BGlycogen synthase kinase-3 betaP49841
GSTM1Glutathione S-transferase Mu 1P09488
GSTP1Glutathione S-transferase PP09211
HIF1AHypoxia-inducible factor 1-alphaQ16665
HSPB1Heat shock protein beta-1P04792
ICAM1Intercellular adhesion molecule 1P05362
IFNGInterferon gammaP01579
IGF2Insulin-like growth factor IIP01344
IKBKBInhibitor of nuclear factor kappa-B kinase subunit betaO14920
IL10Interleukin-10P22301
IL1AInterleukin-1 alphaP01583
IL1BInterleukin-1 betaP01584
IL2Interleukin-2P60568
IL6Interleukin-6P05231
JUNTranscription factor AP-1P05412
MAPK1Mitogen-activated protein kinase 1P28482
MAPK14Mitogen-activated protein kinase 14Q16539
MAPK8Mitogen-activated protein kinase 8P45983
MMP1Interstitial collagenaseP03956
MMP272 kDa type IV collagenaseP08253
MMP3Stromelysin-1P08254
MMP9Matrix metalloproteinase-9P14780
MPOMyeloperoxidaseP05164
MYCMyc proto-oncogene proteinP01106
NFE2L2Nuclear factor erythroid 2-related factor 2Q16236
NFKBIANF-kappa-B inhibitor alphaP25963
NOS2Nitric oxide synthase, inducibleP35228
NOS3Nitric oxide synthase, endothelialP29474
NQO1NAD(P)H dehydrogenase [quinone] 1P15559
ODC1Ornithine decarboxylaseP11926
PARP1Poly [ADP-ribose] polymerase 1P09874
PGRProgesterone receptorP06401
PLATTissue-type plasminogen activatorP00750
PLAUUrokinase-type plasminogen activatorP00749
PPARGPeroxisome proliferator-activated receptor gammaP37231
PTGS1Prostaglandin G/H synthase 1P05979
PTGS2Prostaglandin G/H synthase 2P35354
RASSF1Ras association domain-containing protein 1Q9NS23
RB1Retinoblastoma-associated proteinP06400
SELEE-selectinP16581
SERPINE1Plasminogen activator inhibitor 1P05121
SLC6A4Sodium-dependent serotonin transporterP31645
SLPIAntileukoproteinaseP03973
SOD1Superoxide dismutase [Cu-Zn]P00441
SPP1OsteopontinP10451
THBDThrombomodulinP07204
TP53Cellular tumor antigen p53P04637
VCAM1Vascular cell adhesion protein 1P19320
VEGFAVascular endothelial growth factor AP15692