The Therapeutic Potential of Aprepitant in Glioblastoma Cancer Cells through Redox Modification

<div>Stimulation of NK1R using SP is coupled with the reduction in the total antioxidant capacity of U87 cells. When U87 cells were treated with SP at the concentration of 800 nM, there was a significant reduction in the concentration of TAC. However, blockage of NK1R using aprepitant (20 <i>μ</i>M) resulted in an approximately 2-fold increase in the concentration of TAC in U87 cells. Moreover, in the presence of aprepitant, the ability of SP to reduce the concentration of TAC significantly decreased. 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BioMed Research International

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Figure 5

Figure 5: The Therapeutic Potential of Aprepitant in Glioblastoma Cancer Cells through Redox Modification 