Suppressive, Curative, and Prophylactic Effects of Maesa lanceolata Forssk. against Rodent Malaria Parasite Plasmodium berghei

Table 3

Bioactivities of M. lanceolata crude leaf extract and its fractions against the rodent malaria parasite in the four-day suppressive study.

Test substances	Dose/day	% parasitemia	% suppression	Mean survival days
PW	10 ml/kg		0.00
ML	200 mg/kg		42.24^a^b	^b
	400 mg/kg		47.00^a^b	^b
	600 mg/kg		51.31^a^b	^a^b
CQ	25 mg/kg		100.00^a	^a
2% TW-80	10 ml/kg		0.00
CF	200 mg/kg		64.34^a^b^d	^a^b^d
	400 mg/kg		81.28^a^b^e	^a^b^e
	600 mg/kg		66.94^a^b	^a^b
CQ	25 mg/kg		100.00^a	^a
PW	10 ml/kg		0.00
BF	200 mg/kg		34.85^a^b^d^e	^a^b^e
	400 mg/kg		41.84^a^b	^a^b
	600 mg/kg		46.11^a^b	^a^b
CQ	25 mg/kg		100.00^a	^a
PW	10 ml/kg		0.00
DWF	200 mg/kg		31.28^a^b^e	^a^b^d^e
	400 mg/kg		40.00^a^b	^a^b
	600 mg/kg		41.09^a^b	^a^b
CQ	25 mg/kg		100.00^a	28.00 ± 0.00^a

Values are designated as ; ^a compared to PW, ^b to CQ, ^d to 400 mg/kg of test substance, and ^e600 mg/kg of test substance: , , ; PW: pure water; ML: methanol (80%) extract; 2% TW-80: 2% tween 80; CF: chloroform fraction; BF: n-butanol fraction; DWF: distilled water fraction; CQ: chloroquine.