Suppressive, Curative, and Prophylactic Effects of Maesa lanceolata Forssk. against Rodent Malaria Parasite Plasmodium berghei

Table 4

Body weight and temperature of malaria-infected study mice treated with M. lanceolata methanol (80%) leaf extract and solvent fractions in the four-day chemosuppressive study.

Test substances	Dose/day	Body weight (g)			Rectal temperature (°C)
		D0	D4	% change	D0	D4	% change
PW	10 ml/kg			−4.70			−5.10
ML	200 mg/kg			−2.85^b			−3.52
	400 mg/kg			−2.07^b			−3.35
	600 mg/kg			−1.40^b			−2.54
CQ	25 mg/kg			4.49^a			0.67
2% TW-80	10 ml/kg			−7.56			−3.42
CF	200 mg/kg			−4.02^b			−3.13^b^d
	400 mg/kg	26.05 ± 0.75		−0.35^a			−0.44^a
	600 mg/kg			−0.72			−2.02
CQ	25 mg/kg			4.37^a			0.05^a
PW	10 ml/kg			−6.27			−4.86
BF	200 mg/kg			−4.57^b			−1.59^a
	400 mg/kg			−3.76^b			−1.33^a
	600 mg/kg			−3.03^b			−0.93^a
CQ	25 mg/kg			4.52^a			0.10^a
PW	10 ml/kg			−6.94			−6.03
DWF	200 mg/kg			−5.65^b			−1.23^a
	400 mg/kg			−3.74^b			−0.96^a
	600 mg/kg			−3.43^b			−0.89^a
CQ	25 mg/kg			4.93^a			0.76^a

Values are designated as (); ^a compared to PW, ^b to CQ 25 mg, ^d to 400 mg of test substance, and : , , ; PW: pure water 10 ml/kg (negative control); ML: crude extract of M. lanceolata; 2% TW-80: 2% tween 80; CF: chloroform fraction; BF: n-butanol fraction; DWF: distilled water fraction; CQ: chloroquine; D0: values on day 1 (pretreatment); D4: values on day 5 (posttreatment).