Suppressive, Curative, and Prophylactic Effects of Maesa lanceolata Forssk. against Rodent Malaria Parasite Plasmodium berghei

Table 5

Packed cell volume of malaria-infected study mice treated with M. lanceolata methanol (80%) leaf extract in the four-day chemosuppressive study.

Test substances	Dose/day	Packed cell volume
		D0	D4	% change
PW	10 ml/kg			−30.68
ML	200 mg/kg			−25.82^b
	400 mg/kg			−18.98^b
	600 mg/kg			−10.56
CQ	25 mg/kg			2.97^a
2% TW-80	10 ml/kg			−26.99
CF	200 mg/kg			−22.23^b
	400 mg/kg			−12.40^a^b
	600 mg/kg			−16.21^a^b
CQ	25 mg/kg			3.51^a
PW	10 ml/kg			−12.85
BF	200 mg/kg			−7.75^b
	400 mg/kg			−6.66^b
	600 mg/kg			−5.45^a^b
CQ	25 mg/kg			3.74^a
PW	10 ml/kg			−10.58
DWF	200 mg/kg			−8.39^b
	400 mg/kg			−7.71^b
	600 mg/kg			−6.63^b
CQ	25 mg/kg			2.41^a

Values are designated as (); ^a compared to PW, ^b to CQ 25 mg,: , , ; PW: pure water (negative control); ML: crude extract of M. lanceolata; 2% TW-80: 2% tween 80; CF: chloroform fraction; BF: n-butanol fraction; DWF: distilled water fraction; CQ: chloroquine; D0: values (pretreatment) on day 1; D4: values (posttreatment) on day 5.