Suppressive, Curative, and Prophylactic Effects of Maesa lanceolata Forssk. against Rodent Malaria Parasite Plasmodium berghei

Table 8

Weight (body) and temperature (rectal) of malaria-infected study mice treated with 80% methanol extract of M. lanceolata leaves in the chemoprophylactic test.

Test substances	Dose/day	Body weight (g)			Rectal temperature (°C)
		D4	D7	% change	D4	D7	% change
PW	10 ml/kg			−7.12			−5.22
ML	200 mg/kg			−4.00			−3.68^b
	400 mg/kg		31.13 ± 0.84	−3.04			−2.63^a^b
	600 mg/kg			−2.14^a			−1.72^a
CQ	25 mg/kg			0.66^a			−0.09^a

Values are designated as (); ^a compared to PW, ^b to CQ 25 mg,: , , ; PW: pure water (negative control); ML: 80% methanol extract of M. lanceolata; CQ: chloroquine. D4: preinfection values on day 5; D7: postinfection values on day 8.