Immune Infiltration Represents Potential Diagnostic and Prognostic Biomarkers for Esophageal Squamous Cell Carcinoma

Table 2

Different proportions of immune cells and scores determined by CIBERSORT and ESTIMATE algorithms, respectively, in normal and tumor tissues of ESCC.

Elements	Tumor mean	Normal mean	Fold change (T/N)	value
Naive B cells	0.0092	0.0298	0.3087	0.0005
Memory B cells	0.0165	0.0324	0.5093	0.0021
Plasma cells	0.0955	0.1245	0.7671	0.0072
CD8 T cells	0.1339	0.1459	0.9177	0.1571
Naive CD4 T cells	0.0011		NA	0.1250
Resting memory CD4 T cells	0.0846	0.0994	0.8511	0.0584
Activated memory CD4 T cells	0.0658	0.0141	4.6667
Follicular helper T cells	0.0165	0.0141	1.1702	0.7114
Regulatory T cells (Tregs)	0.0295	0.0435	0.6782	0.0011
Gamma delta T cells	0.0101	0.0312	0.3237
Resting NK cells	0.0014	0	NA	0.0365
Activated NK cells	0.0630	0.0703	0.8962	0.0629
Monocytes	0.0525	0.0942	0.5573
M0 macrophages	0.0776	0.0124	6.2581
M1 macrophages	0.1169	0.0396	2.9520
M2 macrophages	0.0897	0.0798	1.1241	0.2369
Resting dendritic cells	0.0378	0.0385	0.9818	0.5005
Activated dendritic cells	0.0070	0.0011	6.3636	0.0501
Resting mast cells	0.0621	0.1015	0.6118
Activated mast cells	0.0151	0.0092	1.6413	0.7812
Eosinophils	0.0112	0.0181	0.6188	0.0051
Neutrophils	0.0030	0.0002	15.0010	0.0045
StromalScore	0.5942	0.3689	1.6107	0.0032
ImmuneScore	1.1312	1.3004	0.8699	0.0118
ESTIMATEScore	1.7255	1.6693	1.0337	0.9394

Note: values were calculated by the Wilcoxon-signed rank test.