Inflammasome Genetic Variants Are Associated with Protection to Clinical Severity of COVID-19 among Patients from Rio de Janeiro, Brazil

Table 3

Association analyses among NLRP3 and CARD8 inflammasome haplotype frequencies and risk/protection factors for disease severity in SARS-CoV-2-infected individuals.

Genes SNP (rs)	Haplotypes	Mild and moderate group	Severe and critical group	Adjusted model
				aOR^a (95% CI)	value^b
	CTGCC	26 (17.11)	181 (25.71)	Reference
	ACACC	10 (6.58)	54 (7.67)	0.78 (0.24-2.56)	0.677
	ACACG	21 (13.82)	112 (15.91)	0.58 (0.25-1.38)	0.220
	ACGCC	4 (2.63)	6 (0.85)	0.11 (0.02-0.69)	0.018
	ACGCG	20 (13.16)	37 (5.26)	0.23 (0.09-0.62)	0.004
NLRP3; rs1539019 rs4612666 rs3806268 rs35829419 rs10754558	ATGAG	2 (1.32)	2 (0.28)	0.1 (0.01-1.62)	0.104
	ATGCC	12 (7.89)	41 (5.82)	0.35 (0.11-1.12)	0.077
	ATGCG	0 (0)	2 (0.28)	NC
	CCACC	17 (11.18)	77 (10.94)	0.77 (0.28-2.1)	0.605
	CCACG	5 (3.29)	21 (2.98)	0.34 (0.07-1.69)	0.186
	CCGAC	0 (0)	1 (0.14)	NC
	CCGCC	24 (15.79)	92 (13.07)	0.37 (0.16-0.86)	0.022
	CCGCG	6 (3.95)	35 (4.97)	1.87 (0.32-11.02)	0.487
	CTACC	1 (0.66)	4 (0.57)	0.67 (0.01-76.67)	0.87
	CTACG	1 (0.66)	1 (0.14)	1.28 (0.01-164.14)	0.921
	CTGAC	1 (0.66)	1 (0.14)	0.04 (0-0.96)	0.047
	CTGAG	0 (0)	10 (1.42)	NC
	CTGCG	2 (1.32)	27 (3.84)	1.96 (0.3-12.75)	0.480
CARD8; rs2043211; rs6509365	AA	99 (65.13)	501 (70.17)	Reference
	AG	3 (1.97)	33 (4.62)	1.7 (0.43-6.75)	0.449
	TA	2 (1.32)	1 (0.14)	NC
	TG	48 (31.58)	179 (25.07)	0.61 (0.37-1.02)	0.062

^aOdds ratios were adjusted by skin color, schooling, gender, age, and associated comorbidities, such as diabetes mellitus, coronary artery disease, and obesity or previous bariatric disease. ^b values were calculated using the unconditional logistic regression model. Associations were considered significant at a value of . aOR: adjusted odds ratio; 95% CI: 95% confidence interval; NC: not calculated; : number of individuals in each group.