miRNA-Gene Interaction Network Construction Strategy to Discern Promising Traditional Chinese Medicine against Osteoporosis

Figure 2

Identification of osteoporosis-associated mRNAs. (a) The soft thresholding power β was selected as 15 (sale free ) to ensure a scale-free network. (b) Hierarchical clustering tree and the module colors were plotted to display the modules. (c) Nine modules were obtained with Pearson’s correlation coefficients and values. (d) The differentially expressed genes were screened out in 17 osteoporosis and 19 healthy samples with the cutoff criteria adjusted value < 0.01 and . (e) Venn diagram displayed the shared miRNAs between 1,572 differentially expressed genes and 3,344 genes in the turquoise module.

(a)

(b)

(c)

(d)

(e)

(f)