Recent Evidence of Tea Tree Oil Effectiveness in Blepharitis Treatment

Table 1

Summary chart of effectiveness of TTO treatment tested in vitro.

Author	Purpose of study	Results
Cheng et al.	To assess the vitality of 93 live Demodex mites for 300 minutes, based on limb and body movement and crenated or translucent appearance, after the application of four eyelid cleansers and four antimicrobial solutions (TTO 50% diluted and 100% undiluted, T4O, linalool).	No significant differences were observed between undiluted TTO, T4O, and linalool () undiluted linalool and T4O showed comparable antiparasitic efficacy.
Chen et al.	To evaluate the potential toxicity of T4O on epithelial cells of the meibomian glands with variable T4O concentrations (1.0%, 0.1%, and 0.01%).	TTO is toxic on nonocular epithelial cells and on epithelial cells of the meibomian glands for all tested concentrations.
Su et al.	Alcami corporation wanted to evaluate the antibacterial activity of a 2% T4O formulation against pathogens specified in chapter 51 of the United States Pharmacopeia (USP 51>).	T40 2% formulation is safe and effective in rapidly killing microorganisms associated with ocular diseases.
Bulut and Tanriverdi	The purpose of this study was to see how TTO active components in eye washing wipes and mixtures affected Demodex life span.	Even at relatively low doses, T4O has an anti-Demodex action (0.5%).