Preliminary Study of Gastroprotective Effect of Aloe perryi and Date Palm Extracts on Pyloric Ligation-Induced Gastric Ulcer in Experimental Rats

Figure 5

Representative photomicrographs showing H&E-stained rat gastric sections. H&E-stained gastric sections revealed normal mucosal parts (arrowhead) followed by denuded part and remnant glands (thick arrow) without mucosal cells covered, congested blood vessels (thin arrow), and huge submucosal edema with lymphocytic infiltration and inflammatory aggregates (stars) (×100 magnification) (a). High magnification of the ulcerative surface with disruption and complete losses of all mucosal covered epithelium (gastric pits) and still low parts of the glandular layer which mixed with erythrocytes and individual inflammatory cells and/or destructed necrotic cells and congested deep blood vessels (arrow) (400x magnification in the control group) (b, c). Representative of the restoration of the mucosal structure (thick arrow) with still denuded and inflammatory cells individually between gastric glands (thin arrow) (100x magnification: amelioration findings in each APLE 250 mg/kg and DSPE 250 mg/kg group) (d). Representative of the restoration of mucosal surface structure with still minute ulceration surface (arrowhead) with mucosal necrosis and inflammatory cell aggregations (star) beside engorged blood vessels (thin arrow) (100x magnification: amelioration findings in each red oil DPSE 250 mg/kg, yellow oil DPSE, DSPE 500 mg/kg, APFE 500 mg/kg, and APLE 500 mg/kg) (f). Remodeling of all gastric structure layers with prominent normal gastric mucosa (100x magnification: amelioration findings in each red oil DPSE 500 mg/kg, ranitidine, and APFE 500 mg/kg group) (e).

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