Review Article

Analysis of the Research Hotspot of Drug Treatment of Tuberculosis: A Bibliometric Based on the Top 50 Cited Literatures

Table 1

The top 50 cited literatures on drug therapy for tuberculosis.

TitleJournalArticle typeResearch contents/drugsTotal citationPublication yearPage numberPMID

Tuberculosis associated with infliximab, a tumor necrosis factor (alpha)-neutralizing agent [27]New England Journal of MedicineArticleInfliximab26892001611596589
American Thoracic Society/Centers for Disease Control and Prevention/Infectious Diseases Society of America: treatment of tuberculosis [28]American Journal of Respiratory and Critical Care MedicineReviewTherapeutic monitoring138020035912588714
The emergence of drug-resistant tuberculosis in New York City [29]New England Journal of MedicineArticleDrug-resistant, rifapentine, isoniazid, HIV coinfection786199358381207
A small-molecule nitroimidazopyran drug candidate for the treatment of tuberculosis [30]NatureArticleNitroimidazopyran7722000410879539
The challenge of new drug discovery for tuberculosis [31]NatureReviewNew drugs7572011721270886
Multidrug-resistant and extensively drug-resistant tuberculosis: a threat to global control of tuberculosis [32]LancetArticleDrug resistance71620101320488523
Global surveillance for antituberculosis-drug resistance, 1994-1997 [33]New England Journal of MedicineArticleDrug resistance, isoniazid, rifampin, pyrazinamide, ethambutol706199889614254
An official ATS statement: hepatotoxicity of antituberculosis therapy [34]American Journal of Respiratory and Critical Care MedicineReviewHepatotoxicity67520061717021358
Treatment of 171 patients with pulmonary tuberculosis resistant to isoniazid and rifampin [35]New England Journal of MedicineArticleDrug resistance, isoniazid, rifampin627199358426619
The diarylquinoline TMC207 for multidrug-resistant tuberculosis [10]New England Journal of MedicineArticleTMC207, drug-resistant5902009819494215
Anti-tumour necrosis factor agents and tuberculosis risk: mechanisms of action and clinical management [36]Lancet Infectious DiseasesReviewInfliximab, etanercept5712003712614731
Advances in the development of new tuberculosis drugs and treatment regimens [37]Nature Reviews Drug DiscoveryReviewNew drug regimen56720131623629506
Drug-therapy - treatment of multidrug-resistant tuberculosis [38]New England Journal of MedicineReviewDrug resistance555199378350889
Incidence of serious side effects from first-line antituberculosis drugs among patients treated for active tuberculosis [39]American Journal of Respiratory and Critical Care MedicineArticleAdverse reactions, isoniazid, rifampin, pyrazinamide, ethambutol5262003512569078
Three months of rifapentine and isoniazid for latent tuberculosis infection [40]New England Journal of MedicineArticleLatent tuberculosis, rifapentine, isoniazid51420111122150035
The effect of directly observed therapy on the rates of drug-resistance and relapse in tuberculosis [41]New England Journal of MedicineArticleDirectly observed treatment, drug resistance496199458139628
Delamanid for multidrug-resistant pulmonary tuberculosis [11]New England Journal of MedicineArticleDelamanid (OPC-67683), drug-resistant4882012922670901
Efficacy of various durations of isoniazid preventive therapy for tuberculosis - 5 years of follow-up in the IUAT trial [42]Bulletin of The World Health OrganizationArticleIsoniazid484198296754120
Effectiveness of recommendations to prevent reactivation of latent tuberculosis infection in patients treated with tumor necrosis factor antagonists [43]Arthritis and RheumatismArticleInfliximab, latent tuberculosis4842005615934089
Timing of initiation of antiretroviral drugs during tuberculosis therapy [44]New England Journal of MedicineArticle, trailAntiretroviral therapy, HIV coinfection4832010920181971
Literatures on the treatment of tuberculosis undertaken by the British Medical Research Council Tuberculosis Units, 1946-1986, with relevant subsequent publications [45]International Journal of Tuberculosis and Lung DiseaseReviewIsoniazid, rifampicin, pyrazinamide, ethambutol, streptomycin47619994810529902
Standard short-course chemotherapy for drug-resistant tuberculosis - treatment outcomes in 6 countries [46]JAMA-Journal of the American Medical AssociationArticleDrug-resistant, isoniazid, rifampicin, pyrazinamide, ethambutol, streptomycin4652000810815117
Treatment of tuberculosis in patients with advanced human-immunodeficiency-virus infection [47]New England Journal of MedicineArticleHIV coinfection, isoniazid, rifampin, pyrazinamide, ethambutol451199151898769
Antituberculosis drugs: ten years of research [48]Bioorganic & Medicinal ChemistryReviewNew drugs43920073417291770
Short, highly effective, and inexpensive standardized treatment of multidrug-resistant tuberculosis [49]American Journal of Respiratory and Critical Care MedicineArticleDrug-resistant, gatifloxacin, clofazimine, ethambutol, pyrazinamide, prothionamide, kanamycin, isoniazid4362010820442432
High-dose vitamin D-3 during intensive-phase antimicrobial treatment of pulmonary tuberculosis: a double-blind randomised controlled trial [50]LancetArticleVitamin D, supplementary4272011821215445
Supplement – American Thoracic Society Centers for Disease Control and Prevention – targeted tuberculin testing and treatment of latent tuberculosis infection [51]American Journal of Respiratory and Critical Care MedicineReviewLatent tuberculosis infection, rifampin41520002710764341
Antituberculosis drug-induced hepatotoxicity: concise up-to-date review [52]Journal of Gastroenterology and HepatologyReviewHepatotoxicity, first-line drugs41020081117995946
Chemotherapy and management of tuberculosis in the United Kingdom: recommendations 1998 [53]ThoraxReviewGuidelines on chemotherapy4091998129797751
Multidrug resistant pulmonary tuberculosis treatment regimens and patient outcomes: an individual patient data meta-analysis of 9,153 patients [54]Plos MedicineReviewDrug-resistant, fluoroquinolones, ethionamide, prothionamide4072012022952439
Treatment outcomes among patients with multidrug-resistant tuberculosis: systematic review and meta-analysis [55]Lancet Infectious DiseasesReviewDrug-resistant, treatment regimens4062009819246019
WHO guidelines for the programmatic management of drug-resistant tuberculosis: 2011 update [56]European Respiratory JournalArticleGuidelines, drug-resistant40520111221828024
Timing of antiretroviral therapy for HIV-1 infection and tuberculosis [57]New England Journal of MedicineArticleAntiretroviral therapy, HIV coinfection4032011922010914
The potential advantages of nanoparticle drug delivery systems in chemotherapy of tuberculosis [58]American Journal of Respiratory and Critical Care MedicineArticleNanoparticle-based drug delivery systems4032005416151040
Effect of isoniazid prophylaxis on incidence of active tuberculosis and progression of HIV-infection [59]LancetArticleIsoniazid, HIV coinfection397199348101302
Community-based therapy for multidrug-resistant tuberculosis in Lima, Peru [60]New England Journal of MedicineArticleDrug-resistant, pyrazinamide, ethambutol3922003912519922
Multidrug-resistant tuberculosis and culture conversion with bedaquiline [61]New England Journal of MedicineArticleBedaquiline (Sirturo, TMC207), drug-resistant38720141025140958
Best drug treatment for multidrug-resistant and extensively drug-resistant tuberculosis [62]Lancet Infectious DiseasesArticleDrug-resistant, multiple drugs3792010920797644
Linezolid for treatment of chronic extensively drug-resistant tuberculosis [63]New England Journal of MedicineArticleLinezolid, drug-resistant36520121123075177
Integration of antiretroviral therapy with tuberculosis treatment [64]New England Journal of MedicineArticleIntegrating antiretroviral therapy, HIV coinfection35820111022010915
Efficacy of trimethoprim-sulphamethoxazole prophylaxis to decrease morbidity and mortality in HIV-1-infected patients with tuberculosis in Abidjan, Cote d’Ivoire: a randomised controlled trial [65]LancetArticleTrimethoprim-sulphamethoxazole, HIV coinfection3551999710232312
Four-month moxifloxacin-based regimens for drug-sensitive tuberculosis [66]New England Journal of MedicineArticleMoxifloxacin, isoniazid, rifampin, pyrazinamide, ethambutol35520141125196020
Toxic hepatitis with isoniazid and rifampin – a meta-analysis [67]ChestReviewHepatotoxicity, isoniazid, rifampin344199171824929
Prospects for worldwide tuberculosis control under the WHO DOTS strategy [68]LancetArticleShort-course drug regimen, HIV coinfection342199869863786
Polymorphism of the N-acetyltransferase 2 gene as a susceptibility risk factor for antituberculosis drug-induced hepatitis [69]HepatologyArticleHepatotoxicity, isoniazid, genotyped NAT23372002711915035
A trial of three regimens to prevent tuberculosis in Ugandan adults infected with the human immunodeficiency virus [70]New England Journal of MedicineArticleFirst-line drugs, HIV coinfection336199789295239
Hepatotoxicity associated with isoniazid preventive therapy – a 7-year survey from a public health tuberculosis clinic [71]JAMA-Journal of the American Medical AssociationArticleIsoniazid, hepatotoxicity3361999510086436
The magic bullets and tuberculosis drug targets [72]Annual Review of Pharmacology and ToxicologyReview; book chapterChemotherapy review32220053615822188
Rifapentine and isoniazid once a week versus rifampicin and isoniazid twice a week for treatment of drug-susceptible pulmonary tuberculosis in HIV-negative patients: a randomised clinical trial [73]LancetArticleRifapentine, isoniazid3182002712241657
Vitamin D as supplementary treatment for tuberculosis a double-blind, randomized, placebo-controlled trial [74]American Journal of Respiratory and Critical Care MedicineArticleVitamin D, supplementary3082009819179490