Metabolomics Analysis Reveals Alterations in Cochlear Metabolic Profiling in Mice with Noise-Induced Hearing Loss

Table 1

Endogenous differential metabolites of the cochlea between noise-exposed and control groups.

No.	Metabolites	Retention time (min)	Quant mass ()	VIP	value	Fold change
1	Spermidine	14.89	100.02	2.31	<0.001	2.85
2	3-Hydroxybutyric acid	8.15	147.00	2.25	0.013	2.85
3	Glucose-6-phosphate	20.40	147.03	2.25	0.021	0.36
4	Phenylethylamine	9.99	299.46	2.23	0.045	0.33
5	Thymine	12.68	255.01	2.19	0.049	0.32
6	D-Fructose	16.44	102.97	2.12	0.047	0.35
7	3,4-Dihydroxycinnamic acid	20.39	219.10	2.03	0.011	0.42
8	Arbutin	14.84	243.08	1.96	0.036	0.42
9	Hypoxanthine	21.23	264.99	1.93	0.010	0.46
10	4-Aminobutyric acid	15.46	174.02	1.84	0.028	0.48
11	5,6-Dihydrouracil	14.84	128.01	1.77	0.031	0.50
12	Triacontanol	24.45	102.91	1.67	0.019	0.55
13	Orotic acid	20.07	254.00	1.66	0.009	1.78
14	1-Hexacosanol	24.44	299.17	1.64	0.020	0.56
15	Adenine	12.64	239.03	1.51	0.045	0.58
16	4-Aminobenzoicacid	12.50	103.03	1.26	0.050	0.68
17	Salicylaldehyde	11.99	192.98	1.26	0.033	0.70

VIP: variable importance in projection.