Metabolomics Analysis Reveals Alterations in Cochlear Metabolic Profiling in Mice with Noise-Induced Hearing Loss
Table 2
Significantly altered pathways affected by noise exposure.
No.
Pathway name
Total compounds1
Hits2
value
FDR correction3
Rich factor4
1
β-Alanine metabolism
32
3
<0.001
3.74
0.006
0.09
2
Pyrimidine metabolism
65
3
0.001
2.83
0.024
0.05
3
cAMP signaling pathway
25
2
0.004
2.44
0.038
0.08
4
Butanoate metabolism
42
2
0.010
2.00
0.080
0.05
5
Synthesis and degradation of ketone bodies
6
1
0.022
1.66
0.096
0.17
6
Arginine and proline metabolism
78
2
0.032
1.49
0.096
0.03
7
GABAergic synapse
9
1
0.033
1.48
0.096
0.11
8
Insulin secretion
12
1
0.044
1.36
0.106
0.08
9
Purine metabolism
95
2
0.046
1.33
0.106
0.02
1Total compounds: the total number of compounds in the pathway. 2Hits: the number of differential metabolites involved in this pathway. 3FDR correction: the value adjusted by false discovery rate. 4Rich factor: the ratio of the number of differential metabolites to the total number of metabolites in this pathway.
