Research Article
[Retracted] Global Increase in Breast Cancer Incidence: Risk Factors and Preventive Measures
Table 2
Genes, mutation type, and biochemical product active in breast cancer [
224].
| Gene | Biochemical function | Location | Mutation type | Product Type |
| BRCA1 | DNA repair | 117q21.31 | Germinal/somatic | Protein coding | BRCA2 | DNA repair | 13q13.1 | Germline/somatic | Protein coding | PIK3CA | Regulate p110 alpha | 3q26.32 | Somatic | Protein coding | MYC | Cellular signalling | 8q24.21 | Somatic | Protein coding | PTEN | Block PI3K signalling | 10q23.31 | Somatic/germinal | Protein coding | CCND1 | Cell cycle | 11q13.3 | Somatic | Protein coding | ERBB2 | Kinase | 17q12 | Somatic | Protein coding | ERBB3 | Kinase | 12q13.2 | Somatic | Protein coding | FGFR1 | Receptor | 1 8p11.23 | Somatic | Protein coding | FGFR2 | Receptor | 10q26.13 | Somatic/germinal? | Protein coding | GATA3 | Transcriptional factor | 10p14 | Somatic | Protein coding | AKT2 | Kinase | 19q13.2 | Somatic | Protein coding | ARID1B | Chromatin remodelling | 6q25,3 | Somatic | Protein coding | CASP8 | Apoptosis | 2q33.1 | Somatic/germinal? | Protein coding | CDKN1B | Cell cycle control | 12p13.1 | Somatic | Protein coding | MAP3K1 | Kinase | 5q11.2 | Somatic/germinal? | Protein coding | MAP3K13 | Kinase | 3q27.2 | Somatic | Protein coding | NCOR1 | Transcriptional coregulator | 17p12-p | Somatic | Protein coding | SMARCD1 | Chromatin remodelling | 12q13.12 | Somatic | Protein coding | TBX3 | Transcriptional repressor | 12q24.21 | Somatic | Protein coding | RB1 | Cell cycle regulator | 13q14.2 | Somatic | protein coding | ESR1 | Receptor | 6q25.1-q25.2 | Somatic | Protein coding | FOXA1 | Transcriptional factor | 14q21.1 | Somatic | Protein coding | CDH1 | ECM signalling | 16q22.1 | Somatic/germinal | Protein coding | APOBEC3B | Innate immunity | 22q13.1 | Somatic | Protein coding | PALB2 | DNA repair | 16p12.2 | Germinal/somatic? | Protein coding | ATM | DNA repair | 11q22.3 | Germinal/somatic | Protein coding | CHEK2 | DNA repair | 22q12.1 | Germinal/somatic | Protein coding | RAD51 | Homologous recombination | 15q15.1 | Germinal | Protein coding | RAD51C | Homologous recombination | 17q22 | Germinal/somatic? | Protein coding | MSH2 | DNA mismatch repair | 2p21-p16 | Germinal/somatic | Protein coding | BARD1 | DNA repair | 2q35 | Germinal/somatic? | Protein coding | STK11 | Kinase | 19p13.3 | Germinal/somatic | Protein coding | BRIP1 | DNA repair | 17q23.2 | Germinal/somatic | Protein coding | MALAT1 | Long noncoding RNA | 11q13.1 | Somatic | Nonprotein coding | HOTAIR | Long noncoding RNA | 12q13.13 | Somatic | Nonprotein coding | MEG3 | Long noncoding RNA | 14q32.2 | Somatic | Nonprotein coding | H19 | Long noncoding RNA | 11p15.5 | Somatic | Nonprotein coding |
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