[Retracted] Global Increase in Breast Cancer Incidence: Risk Factors and Preventive Measures

Table 2

Genes, mutation type, and biochemical product active in breast cancer [224].

Gene	Biochemical function	Location	Mutation type	Product Type
BRCA1	DNA repair	117q21.31	Germinal/somatic	Protein coding
BRCA2	DNA repair	13q13.1	Germline/somatic	Protein coding
PIK3CA	Regulate p110 alpha	3q26.32	Somatic	Protein coding
MYC	Cellular signalling	8q24.21	Somatic	Protein coding
PTEN	Block PI3K signalling	10q23.31	Somatic/germinal	Protein coding
CCND1	Cell cycle	11q13.3	Somatic	Protein coding
ERBB2	Kinase	17q12	Somatic	Protein coding
ERBB3	Kinase	12q13.2	Somatic	Protein coding
FGFR1	Receptor	1 8p11.23	Somatic	Protein coding
FGFR2	Receptor	10q26.13	Somatic/germinal?	Protein coding
GATA3	Transcriptional factor	10p14	Somatic	Protein coding
AKT2	Kinase	19q13.2	Somatic	Protein coding
ARID1B	Chromatin remodelling	6q25,3	Somatic	Protein coding
CASP8	Apoptosis	2q33.1	Somatic/germinal?	Protein coding
CDKN1B	Cell cycle control	12p13.1	Somatic	Protein coding
MAP3K1	Kinase	5q11.2	Somatic/germinal?	Protein coding
MAP3K13	Kinase	3q27.2	Somatic	Protein coding
NCOR1	Transcriptional coregulator	17p12-p	Somatic	Protein coding
SMARCD1	Chromatin remodelling	12q13.12	Somatic	Protein coding
TBX3	Transcriptional repressor	12q24.21	Somatic	Protein coding
RB1	Cell cycle regulator	13q14.2	Somatic	protein coding
ESR1	Receptor	6q25.1-q25.2	Somatic	Protein coding
FOXA1	Transcriptional factor	14q21.1	Somatic	Protein coding
CDH1	ECM signalling	16q22.1	Somatic/germinal	Protein coding
APOBEC3B	Innate immunity	22q13.1	Somatic	Protein coding
PALB2	DNA repair	16p12.2	Germinal/somatic?	Protein coding
ATM	DNA repair	11q22.3	Germinal/somatic	Protein coding
CHEK2	DNA repair	22q12.1	Germinal/somatic	Protein coding
RAD51	Homologous recombination	15q15.1	Germinal	Protein coding
RAD51C	Homologous recombination	17q22	Germinal/somatic?	Protein coding
MSH2	DNA mismatch repair	2p21-p16	Germinal/somatic	Protein coding
BARD1	DNA repair	2q35	Germinal/somatic?	Protein coding
STK11	Kinase	19p13.3	Germinal/somatic	Protein coding
BRIP1	DNA repair	17q23.2	Germinal/somatic	Protein coding
MALAT1	Long noncoding RNA	11q13.1	Somatic	Nonprotein coding
HOTAIR	Long noncoding RNA	12q13.13	Somatic	Nonprotein coding
MEG3	Long noncoding RNA	14q32.2	Somatic	Nonprotein coding
H19	Long noncoding RNA	11p15.5	Somatic	Nonprotein coding