Research Article
Circadian Clock Genes Act as Diagnostic and Prognostic Biomarkers of Glioma: Clinic Implications for Chronotherapy
Table 1
Univariate analysis and multivariate analysis of clinicopathological characteristics and CCGs for overall survival in glioma patients from TCGA.
| Variables | Total | Univariate analysis | Multivariate analysis | (%) | HR (95% CI) | | HR (95% CI) | |
| Age | | | | | | <60 | 483 (76.9%) | 1 (reference) | | 1 (reference) | | ≥60 | 145 (23.1%) | 1.073 (1.062-1.085) | | 1.047 (1.034-1.062) | | Gender | | | | | | Female | 270 (43.0%) | 1 (reference) | | | | Male | 358 (57.0%) | 1.08 (0.821-1.419) | | | | Grade | | | | | | G2+G3 | 476 (75.8%) | 1 (reference) | | 1 (reference) | | G4 | 152 (24.2%) | 9.553 (7.036-12.97) | | 1.802 (1.168-2.779) | | ARNTL | | | | | | Low exp | 336 (53.5%) | 1 (reference) | | 1 (reference) | | High exp | 292 (46.5%) | 2.612 (2.165-3.145) | | 1.525 (1.219-1.908) | | CLOCK | | | | | | Low exp | 304 (48.4%) | 1 (reference) | | | | High exp | 324 (51.6%) | 0.565 (0.440-0.727) | | | | CRY1 | | | | | | Low exp | 329 (52.4%) | 1 (reference) | | | | High exp | 299 (47.6%) | 2.102 (1.555-2.842) | | | | CRY2 | | | | | | Low exp | 274(43.6%) | 1 (reference) | | 1 (reference) | | High exp | 354(56.4%) | 0.426 (0.375-0.484) | | 0.666 (0.522-0.85) | | DBP | | | | | | Low exp | 293 (46.6%) | 1 (reference) | | | | High exp | 335 (53.4%) | 0.49 (0.416-0.576) | | | | NPAS2 | | | | | | Low exp | 319 (50.8%) | 1 (reference) | | 1 (reference) | | High exp | 309 (49.2%) | 1.431 (1.237-1.654) | | 1.234[1.034-1.472] | | NR1D1 | | | | | | Low exp | 306 (48.7%) | 1 (reference) | | | | High exp | 322 (51.3%) | 0.613 (0.526-0.713) | | | | NR1D2 | | | | | | Low exp | 271 (43.2%) | 1 (reference) | | | | High exp | 357 (56.8%) | 0.352 (0.297-0.417) | | | | PER1 | | | | | | Low exp | 275 (43.8%) | 1 (reference) | | | | High exp | 353 (56.2%) | 0.853 (0.737-0.987) | | | | PER2 | | | | | | Low exp | 294 (46.8%) | 1 (reference) | | | | High exp | 334 (53.2%) | 0.464 (0.385-0.559) | | | | PER3 | | | | | | Low exp | 285 (45.4%) | 1 (reference) | | | | High exp | 343 (54.6%) | 0.489 (0.434-0.551) | | | | RORA | | | | | | Low exp | 297 (47.3%) | 1 (reference) | | 1 (reference) | | High exp | 331 (52.7%) | 0.584 (0.498-0.685) | | 0.745 (0.566-0.981) | | TIMELESS | | | | | | Low exp | 343 (54.6%) | 1 (reference) | | 1 (reference) | | High exp | 285 (45.4%) | 2.051 (1.775-2.369) | | 1.39 (1.132-1.707) | |
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