Circadian Clock Genes Act as Diagnostic and Prognostic Biomarkers of Glioma: Clinic Implications for Chronotherapy

Table 1

Univariate analysis and multivariate analysis of clinicopathological characteristics and CCGs for overall survival in glioma patients from TCGA.

Variables	Total	Univariate analysis		Multivariate analysis
	(%)	HR (95% CI)		HR (95% CI)
Age
<60	483 (76.9%)	1 (reference)		1 (reference)
≥60	145 (23.1%)	1.073 (1.062-1.085)		1.047 (1.034-1.062)
Gender
Female	270 (43.0%)	1 (reference)
Male	358 (57.0%)	1.08 (0.821-1.419)
Grade
G2+G3	476 (75.8%)	1 (reference)		1 (reference)
G4	152 (24.2%)	9.553 (7.036-12.97)		1.802 (1.168-2.779)
ARNTL
Low exp	336 (53.5%)	1 (reference)		1 (reference)
High exp	292 (46.5%)	2.612 (2.165-3.145)		1.525 (1.219-1.908)
CLOCK
Low exp	304 (48.4%)	1 (reference)
High exp	324 (51.6%)	0.565 (0.440-0.727)
CRY1
Low exp	329 (52.4%)	1 (reference)
High exp	299 (47.6%)	2.102 (1.555-2.842)
CRY2
Low exp	274(43.6%)	1 (reference)		1 (reference)
High exp	354(56.4%)	0.426 (0.375-0.484)		0.666 (0.522-0.85)
DBP
Low exp	293 (46.6%)	1 (reference)
High exp	335 (53.4%)	0.49 (0.416-0.576)
NPAS2
Low exp	319 (50.8%)	1 (reference)		1 (reference)
High exp	309 (49.2%)	1.431 (1.237-1.654)		1.234[1.034-1.472]
NR1D1
Low exp	306 (48.7%)	1 (reference)
High exp	322 (51.3%)	0.613 (0.526-0.713)
NR1D2
Low exp	271 (43.2%)	1 (reference)
High exp	357 (56.8%)	0.352 (0.297-0.417)
PER1
Low exp	275 (43.8%)	1 (reference)
High exp	353 (56.2%)	0.853 (0.737-0.987)
PER2
Low exp	294 (46.8%)	1 (reference)
High exp	334 (53.2%)	0.464 (0.385-0.559)
PER3
Low exp	285 (45.4%)	1 (reference)
High exp	343 (54.6%)	0.489 (0.434-0.551)
RORA
Low exp	297 (47.3%)	1 (reference)		1 (reference)
High exp	331 (52.7%)	0.584 (0.498-0.685)		0.745 (0.566-0.981)
TIMELESS
Low exp	343 (54.6%)	1 (reference)		1 (reference)
High exp	285 (45.4%)	2.051 (1.775-2.369)		1.39 (1.132-1.707)