Circadian Clock Genes Act as Diagnostic and Prognostic Biomarkers of Glioma: Clinic Implications for Chronotherapy
Table 2
Univariate analysis and multivariate analysis of clinicopathological characteristics and CCGs for overall survival in glioma patients from CGGA.
Variables
Total
Univariate analysis
Multivariate analysis
(%)
HR (95% CI)
HR (95% CI)
Age
<60
847 (88.1%)
1 (reference)
1 (reference)
≥60
113 (11.9%)
1.029 (1.022-1.036)
1.015 (1.008-1.022)
Gender
Female
397 (41.3%)
1 (reference)
Male
564 (58.7%)
1.015 (0.862-1.194)
Grade
G2+G3
590 (61.4%)
1 (reference)
1 (reference)
G4
371 (38.6%)
4.151 (3.509-4.912)
1.971 (1.600-2.429)
ARNTL
Low exp
450 (46.8%)
1 (reference)
High exp
511 (53.2%)
1.282 (1.173-1.4)
CLOCK
Low exp
510 (53.1%)
1 (reference)
High exp
451 (46.9%)
1.208 (1.080-1.352)
CRY1
Low exp
466 (48.5%)
1 (reference)
High exp
495 (51.5%)
1.338 (1.225-1.463)
CRY2
Low exp
467(48.6%)
1 (reference)
1 (reference)
High exp
494 (51.4%)
0.484 (0.441-0.53)
0.679 (0.582-0.793)
DBP
Low exp
447 (46.5%)
1 (reference)
1 (reference)
High exp
514 (53.5%)
0.763 (0.714-0.816)
0.872 (0.775-0.981)
NPAS2
Low exp
489 (50.9%)
1 (reference)
High exp
472 (49.1%)
1.317 (1.204-1.441)
NR1D1
Low exp
436 (45.4%)
1 (reference)
High exp
525 (54.6%)
0.834 (0.773-0.899)
NR1D2
Low exp
471 (49.0%)
1 (reference)
High exp
490 (51.0%)
0.716 (0.649-0.789)
PER1
Low exp
433 (45.1%)
1 (reference)
High exp
528 (54.9%)
1.007 (0.943-1.074)
PER2
Low exp
495 (51.5%)
1 (reference)
High exp
466 (48.5%)
0.66 (0.562-0.774)
PER3
Low exp
486 (50.6%)
1 (reference)
High exp
475 (49.4%)
0.767 (0.703-0.836)
RORA
Low exp
465 (48.4%)
1 (reference)
1 (reference)
High exp
496 (51.6%)
0.842 (0.745-0.952)
0.854 (0.731-0.999)
TIMELESS
Low exp
513 (53.4%)
1 (reference)
1 (reference)
High exp
448 (46.6%)
1.722 (1.595-1.859)
1.335 (1.196-1.491)
Notes: characteristics with in the univariate analysis were further screened in the multivariate analysis. Exp: expression; HR: hazard ratio; CI: confidence interval; ,, and .
