Circadian Clock Genes Act as Diagnostic and Prognostic Biomarkers of Glioma: Clinic Implications for Chronotherapy

Table 3

Correlation analysis between four key CCGs and immune cell biomarkers for glioma.

Immune cells	Biomarkers	ARNTL		NPAS2		CRY2		DBP
			Cor		Cor		Cor		Cor
CD8 + T cell	CD8A		0.14		0.31		-0.27		-0.09
	CD8B		0.16		0.22		-0.32		-0.11
T cell (general)	CD3D		0.13		0.17		-0.37		-0.12
	CD3E		0.09		0.22		-0.34		-0.1
	CD2		0.14		0.21		-0.37		-0.13
B cell	CD19	0.99	0	0.31	0.03		-0.16	0.78	0.01
	CD79A	0.84	0.01	0.69	0.01		-0.15	0.66	-0.01
Tumor-associated macrophage (TAM)	CCL2		0.15		0.17		-0.24		-0.13
	CD68	0.07	0.07		0.09		-0.4		-0.15
	IL10		0.15		0.12		-0.33		-0.18
Neutrophils	CD66b (CEACAM8)	0.4	0.03	0.98	0		-0.08	0.15	-0.05
	CD11b (ITGAM)	0.35	0.03		0.12		-0.36	0.39	-0.03
	CCR7	0.13	0.06		0.16		-0.23		-0.13
Natural killer cell	KIR2DL4	0.65	0.02	0.72	0.01		-0.23	0.32	-0.03
	KIR3DL1	0.06	0.07		0.13	0.05	-0.07		-0.09
	KIR2DS4	0.34	0.03	0.08	0.06		-0.17		-0.07
Dendritic cell	HLA-DPB1		0.11		0.13		-0.44		-0.1
	HLA-DQB1		0.15		0.12		-0.4		-0.15
	HLA-DRA		0.19		0.13		-0.49		-0.19
	HLA-DPA1		0.13		0.13		-0.44		-0.17
	BDCA-1 (CD1C)	0.98	0	0.39	0.03		-0.14	0.24	-0.04
	BDCA-4 (NRP1)		0.2		0.44		-0.4		-0.31
	CD11c (ITGAX)	0.24	-0.04	0.92	0		-0.33	0.11	0.059

Notes: Cor: value of Person’s correlation; , , and .