Research Article
DOK5 as a Prognostic Biomarker of Gastric Cancer Immunoinvasion: A Bioinformatics Analysis
Table 1
Kaplan-Meier plotter was used to analyze the correlation between DOK5 mRNA expression and different clinicopathological factors in gastric cancer.
| Clinicopathological factors | Overall survival | Progression-free survival | | Hazard ratio | value | | Hazard ratio | value |
| Sex | Female | 244 | 1.47 (1.03-2.08) | | 201 | 1.46 (1-2.13) | 0.051 | Male | 566 | 1.28 (1.03-1.59) | | 437 | 1.08 (0.85-1.37) | 0.55 | Stage | 1 | 69 | 0.63 (0.23-1.71) | 0.36 | 60 | 0.66 (0.22-2) | 0.46 | 2 | 145 | 1.74 (0.93-3.25) | 0.077 | 131 | 1.5 (0.8-2.79) | 0.2 | 3 | 319 | 1.54 (1.15-2.05) | | 186 | 1.77 (1.21-2.58) | | 4 | 152 | 1.5 (1.02-2.21) | | 141 | 1.41 (0.96-2.07) | 0.083 | Stage T | 1 | 14 | — | — | 14 | — | — | 2 | 253 | 1.87 (1.21-2.9) | | 239 | 1.66 (1.09-2.54) | | 3 | 208 | 1.27 (0.9-1.8) | 0.17 | 204 | 1.22 (0.87-1.7) | 0.24 | 4 | 39 | 1.59 (0.69-3.62) | 0.27 | 39 | 2.49 (1.14-5.47) | | Stage N | 0 | 76 | 1.04 (0.44-2.47) | 0.92 | 72 | 1.21 (0.52-2.8) | 0.66 | 1 | 232 | 2.43 (1.57-3.75) | | 222 | 2.49 (1.64-3.79) | | 2 | 129 | 1.78 (1.13-2.81) | | 125 | 1.56 (1.01-2.41) | | 3 | 76 | 1.88 (1.1-3.22) | | 76 | 1.59 (0.93-2.72) | 0.085 | 1+2+3 | 437 | 1.97 (1.51-2.58) | | 423 | 1.9 (1.47-2.47) | | Stage M | 0 | 459 | 1.8 (1.36-2.39) | | 443 | 1.71 (1.3-2.24) | | 1 | 58 | 1.76 (0.98-3.17) | 0.0573 | 56 | 1.4 (0.77-2.53) | 0.27 | Lauren classification | Intestinal | 336 | 1.95 (1.41-2.7) | | 263 | 1.73 (1.2-2.47) | | Diffuse | 248 | 1.63 (1.16-2.3) | | 231 | 1.67 (1.18-2.37) | | Mixed | 33 | 2.02 (0.72-5.71) | 0.1743 | 28 | 1.67 (0.6-4.68) | 0.32 | Differentiation | Poorly differentiated | 165 | 1.19 (0.8-1.78) | 0.39 | 121 | 1.35 (0.85-2.15) | 0.2 | Moderately differentiated | 67 | 1.41 (0.73-2.69) | 0.3 | 67 | 1.58 (0.85-2.96) | 0.15 | Well differentiated | 32 | 2.45 (1.01-5.95) | | 5 | — | — | HER2 status | HER2 negative | 532 | 1.47 (1.17-1.85) | | 408 | 1.35 (1.04-1.75) | | HER2 positive | 343 | 1.16 (0.9-1.51) | 0.26 | 232 | 1.24 (0.9-1.71) | 0.19 |
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